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- Title
TNF-α modulates the migratory response of mesenchymal stem cells to TRAIL.
- Authors
Corallini, Federica; Secchiero, Paola; Beltrami, Antonio Paolo; Cesselli, Daniela; Puppato, Elisa; Ferrari, Roberto; Beltrami, Carlo Alberto; Zauli, Giorgio
- Abstract
The number of circulating mesenchymal stem cells (MSC), analyzed after acute myocardial infarction (AMI), was lower in AMI patients who developed heart failure (HF) in the follow-up. Conversely, the circulating levels of tumor necrosis factor (TNF)-α, and osteoprotegerin (OPG) were higher in AMI patients who developed HF with respect to the patients who did not develop HF. In vitro exposure to TNF-α enhanced the migration of MSC in response to TNF-related apoptosis-inducing ligand (TRAIL) and significantly increased the release of OPG by endothelial cells. On the contrary, OPG dose-dependently neutralized the in vitro pro-migratory activity of TRAIL. Thus, TNF-α exhibits opposite effects on MSC migration driven by TRAIL: it is capable of potentiating MSC migration as well as of inhibiting MSC migration as an indirect consequence of OPG induction, which might result in a suboptimal recruitment of circulating MSC after AMI in those patients who develop HF in the follow-up.
- Subjects
TUMOR necrosis factors; STEM cells; MYOCARDIAL infarction; HEART failure; APOPTOSIS
- Publication
Cellular & Molecular Life Sciences, 2010, Vol 67, Issue 8, p1307
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-009-0246-5