We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
SARS-CoV-2 virus dynamics in recently infected people - data from a household transmission study.
- Authors
Mellis, Alexandra M; Meece, Jennifer K; Halasa, Natasha B; Chappell, James D; McLean, Huong Q; Grijalva, Carlos G; Hanson, Kayla E; Zhu, Yuwei; Kim, Ahra; Deyoe, Jessica; Ivacic, Lynn C; Reed, Carrie; Talbot, H Keipp; Rolfes, Melissa A
- Abstract
We used daily real-time reverse-transcription polymerase chain reaction (rRT-PCR) results from 67 cases of SARS-CoV-2 infection in a household transmission study, conducted April 2020--May 2021, to examine the trajectory of cycle threshold (Ct) values, an inverse correlate of viral RNA concentration. Ct values varied across RT-PCR platforms and by participant age. Specimens collected from children and adolescents had higher Ct values and adults aged ≥50 years showed lower Ct values than adults aged 18-49 years. Ct values were lower on days when participants reported experiencing symptoms, with the lowest Ct value occurring 2-6 days after symptom onset.
- Subjects
SARS-CoV-2; POLYMERASE chain reaction; INFECTIOUS disease transmission
- Publication
Journal of Infectious Diseases, 2022, Vol 226, Issue 10, p1699
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiac180