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- Title
Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation.
- Authors
Piñana, Jose Luis; Xhaard, Aliénor; Tridello, Gloria; Passweg, Jakob; Kozijn, Anne; Polverelli, Nicola; Heras, Inmaculada; Perez, Ariadna; Sanz, Jaime; Berghuis, Dagmar; Vázquez, Lourdes; Suárez-Lledó, María; Itäla-Remes, Maija; Ozcelik, Tulay; Basarán, Isabel Iturrate; Karakukcu, Musa; Zahrani, Mohsen Al; Choi, Goda; Casas, Marián Angeles Cuesta; Massana, Montserrat Batlle
- Abstract
<bold>Background: </bold>Little is known about characteristics of seasonal human coronaviruses (HCoVs) (NL63, 229E, OC43, and HKU1) after allogeneic stem cell transplantation (allo-HSCT).<bold>Methods: </bold>This was a collaborative Spanish and European bone marrow transplantation retrospective multicenter study, which included allo-HSCT recipients (adults and children) with upper respiratory tract disease (URTD) and/or lower respiratory tract disease (LRTD) caused by seasonal HCoV diagnosed through multiplex polymerase chain reaction assays from January 2012 to January 2019.<bold>Results: </bold>We included 402 allo-HSCT recipients who developed 449 HCoV URTD/LRTD episodes. Median age of recipients was 46 years (range, 0.3-73.8 years). HCoV episodes were diagnosed at a median of 222 days after transplantation. The most common HCoV subtype was OC43 (n = 170 [38%]). LRTD involvement occurred in 121 episodes (27%). HCoV infection frequently required hospitalization (18%), oxygen administration (13%), and intensive care unit (ICU) admission (3%). Three-month overall mortality after HCoV detection was 7% in the whole cohort and 16% in those with LRTD. We identified 3 conditions associated with higher mortality in recipients with LRTD: absolute lymphocyte count <0.1 × 109/mL, corticosteroid use, and ICU admission (hazard ratios: 10.8, 4.68, and 8.22, respectively; P < .01).<bold>Conclusions: </bold>Seasonal HCoV after allo-HSCT may involve LRTD in many instances, leading to a significant morbidity.
- Subjects
HEMATOPOIETIC stem cell transplantation; CORONAVIRUS diseases; RESPIRATORY infections; RESPIRATORY diseases; BONE marrow transplantation; COVID-19
- Publication
Journal of Infectious Diseases, 2021, Vol 223, Issue 9, p1564
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiaa553