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- Title
Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults.
- Authors
Chen, Sijia; Pawelec, Graham; Trompet, Stella; Goldeck, David; Mortensen, Laust H; Slagboom, P Eline; Christensen, Kaare; Gussekloo, Jacobijn; Kearney, Patricia; Buckley, Brendan M; Ford, Ian; Jukema, J Wouter; Westendorp, Rudi G J; Maier, Andrea B
- Abstract
<bold>Background: </bold>Whether latent cytomegalovirus (CMV) infection in older adults has any substantial health consequences is unclear. Here, we sought associations between CMV-seropositivity and IgG titer with all-cause and cardiovascular mortality in 5 longitudinal cohorts.<bold>Methods: </bold>Leiden Longevity Study, Prospective Study of Pravastatin in the Elderly at Risk, Longitudinal Study of Aging Danish Twins, and Leiden 85-plus Study were assessed at median (2.8-11.4 years) follow-up . Cox regression and random effects meta-analysis were used to estimate mortality risk dependent on CMV serostatus and/or IgG antibody titer, in quartiles after adjusting for confounders.<bold>Results: </bold>CMV-seropositivity was seen in 47%-79% of 10 122 white community-dwelling adults aged 59-93 years. Of these, 3519 had died on follow-up (579 from cardiovascular disease). CMV seropositivity was not associated with all-cause (hazard ratio [HR], 1.05; 95% confidence interval [CI], .97-1.14) or cardiovascular mortality (HR, 0.97; 95% CI, .83-1.13). Subjects in the highest CMV IgG quartile group had increased all-cause mortality relative to CMV-seronegatives (HR, 1.16; 95% CI, 1.04-1.29) but this association lost significance after adjustment for confounders (HR, 1.13; 95% CI, .99-1.29). The lack of increased mortality risk was confirmed in subanalyses.<bold>Conclusions: </bold>CMV infection is not associated with all-cause or cardiovascular mortality in white community-dwelling older adults.
- Subjects
OLDER people; CYTOMEGALOVIRUS diseases; COHORT analysis; SCIENTIFIC observation; ANTIBODY titer; CARDIOVASCULAR disease related mortality; CYTOMEGALOVIRUSES; CAUSES of death; PUBLIC health surveillance; RESEARCH; IMMUNOGLOBULINS; META-analysis; AGE distribution; RESEARCH methodology; GERIATRIC assessment; CARDIOVASCULAR diseases; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; VIRAL antibodies; LONGITUDINAL method; COMORBIDITY; EPIDEMIOLOGICAL research
- Publication
Journal of Infectious Diseases, 2021, Vol 223, Issue 2, p238
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiaa480