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- Title
Dendritic-NK Cell Interactions in P. gingivalis-specific Responses.
- Authors
Kikuchi, T.; Willis, D. L.; Liu, M.; Purkall, D. B.; Sukumar, S.; Barbour, S. E.; Schenkein, H. A.; Tew, J. G.
- Abstract
Patients with localized aggressive periodontitis have type-1 cytokines in gingival crevicular fluid and high titers of IFN-γ-dependent IgG2 reactive with P. gingivalis in gingival crevicular fluid and serum. Localized aggressive periodontitis monocytes spontaneously differentiate into dendritic cells that can stimulate IFN-γ production by NK cells. These relationships prompted the hypothesis that P. gingivalis-dendritic cell-NK cell interactions might promote type-1 cytokine responses. Although P. gingivalis is not a potent inducer of Th1 responses, it stimulated strong IL- 12 responses by monocyte-derived dendritic cells in the presence of IFN-γ, and IFN-γ was produced by NK cells within 24 hrs in the presence of dendritic cells. Anti-P. gingivalis IgG2 responses were enhanced by dendritic cells, and removal of NK cells reduced IFN-γ- and P. gingivalis-specific IgG2. Thus, P. gingivalis-dendritic cell- NK cell interactions apparently resulted in reciprocal stimulation and increased type-1 cytokine production by both dendritic cells and NK cells, and increased P. gingivalis-specific IgG2.
- Subjects
DENDRITIC cells; KILLER cells; CELLS; ANTIGEN presenting cells; LYMPHOID tissue; CELLULAR immunity; GINGIVAL fluid
- Publication
Journal of Dental Research, 2005, Vol 84, Issue 9, p858
- ISSN
0022-0345
- Publication type
Article
- DOI
10.1177/154405910508400915