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- Title
Relationship of serum salusin beta levels with coronary slow flow.
- Authors
Akyüz, Aydın; Aydın, Fatma; Alpsoy, Şeref; Gür, Demet Özkaramanlı; Güzel, Savaş
- Abstract
Objective: The pathophysiology of coronary slow flow (CSF) has not been clarified. Salusin-ß is released predominantly from the atheroma plaques and influences the pathophysiologic processes of atherosclerosis. Therefore, this study aimed to determine serum salusin-ß levels in CSF and its correlation with CSF. Methods: The study included 39 patients with CSF, and the control group (n=42) consisted of consecutive subjects with normal coronary arteriogram. We measured salusin-ß and thrombolysis in myocardial infarction frame count (TFC). Results: Age, body mass index (BMI), systolic blood pressure, diabetes, hyperlipidemia, and smoking rates were similar (p values>0.05) in both groups. High sensitive C-reactive protein (2.80±1.2 vs. 2.21±1.2 mg/dL, p=0.011), salusin-ß [1205 (330-2092) vs. 162 (29-676), pg/ml, p<0.001], corrected TFC of left anterior descending coronary artery (29±9 vs. 19.7±3.7, p<0.001), circumflex artery TFC (25±10 vs. 15±3.2, p<0.001), right coronary artery TFC (28±7.1 vs. 13±3.3, p<0.001), and mean TFC (28±4.4 vs. 16±3.7, p<0.001) were significantly higher in the CSF group. In univariate and multivariate regression analysis, only BMI (unstandardized ß±SE=0.178±0.08, p=0.036) and salusin-ß levels (unstandardized ß±SE=0.006±0.01, p<0.001) were determined as predictors of CSF. There was a good correlation between serum salusin-ß and mean TFC values (r=0.564; p<0.001). Conclusion: There is an association between serum salusin-ß levels and CSF.
- Subjects
SYSTOLIC blood pressure; BODY mass index; CORONARY arteries; SERUM; C-reactive protein
- Publication
Anatolian Journal of Cardiology / Anadolu Kardiyoloji Dergisi, 2019, Vol 22, Issue 4, p177
- ISSN
2149-2263
- Publication type
Article
- DOI
10.14744/AnatolJCardiol.2019.43247