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- Title
Reduced intra‐subject variability of an automated skin prick test device compared to a manual test.
- Authors
Gorris, Senne; Uyttebroek, Saartje; Backaert, Wout; Jorissen, Mark; Schrijvers, Rik; Thompson, Mark J.; Loeckx, Dirk; Seys, Sven F.; Van Gerven, Laura; Hellings, Peter W.
- Abstract
Reduced intra-subject variability of an automated skin prick test device compared to a manual test SPAT showed significantly lower coefficient of variation of the histamine wheal sizes (SPAT median (IQR): 13.6% (10.4%-17.7%)) compared to SPMT (SPMT median: 17.6% (13.6%-22.9%); I p i < 0.0001; Figure 1). To the Editor, Respiratory allergies affect 30%-40% of individuals worldwide and represent a major health-economic problem.[1] Identification of the triggering or causative allergens in symptomatic patients is based on skin prick test or serum-specific IgE analysis in addition to a detailed medical history by the physician.[[2]] Skin prick test (SPT) is the first choice diagnostic instrument according to international guidelines because of reduced cost, faster results, less invasiveness and a better sensitivity-specificity profile compared to extract-based specific IgE analysis.[[4]] However, there is a need for standardized automation of the entire SPT procedure given that SPT exhibits both operator and device-dependent variability.[[6]] A monocentric, prospective diagnostic test accuracy study (ISRCTN14098475) was performed at the University Hospitals of Leuven (UZ Leuven, Belgium) to compare reproducibility, tolerability and safety of a newly developed Skin Prick Automated Test or SPAT (Figure S1A-C) to the Skin Prick Manual Test or SPMT (Figure S1D-F).
- Subjects
SKIN tests; RESPIRATORY allergy; FOOD allergy; ALLERGIC rhinitis
- Publication
Allergy, 2023, Vol 78, Issue 5, p1366
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.15619