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- Title
Pro 12Ala of the Peroxisome Proliferator-Activated Receptor-ϒ2 Gene Is Associated With Lower Serum Insulin Levels in Nonobese African Americans.
- Authors
Kao, W.H. Linda; Coresh, Josef; Shuldiner, Alan R.; Boerwinkle, Eric; Bray, Molly S.; Brancati, Frederick L.
- Abstract
Recent research suggests that the Prol2Ala variant in peroxisome proliferator-activated receptor-γ2 (PPARγ2) is associated with diabetes- and obesity-related traits, and that its effects may be modified by obesity status. We characterized this variant in a population based sample of 1,441 middle-aged African-American individuals with respect to diabetes-, obesity-, and other cardiovascular-related traits, both cross-sectionally and prospectively. The overall frequency of Alal2 was 1.9% (95% CI 1.5-2.5%), significantly lower than in Caucasian populations. Consistent with previous findings in Caucasians, African Americans with type 2 diabetes tended to be less likely to have the Pro/Ala genotype than those without (odds ratio [OR] 0.64, 95% CI 0.341.20); however, this OR was not statistically significant. Among nonobese individuals, the Pro/Ala genotype was associated with significantly lower In(insulin) (P = 0.001), lower ln(HOMA-IR) (homeostasis model assessment of insulin resistance) (P = 0.002), higher fasting glucose-to-insulin ratio (P = 0.005), and lower diastolic blood pressure (P = 0.02). Among overweight individuals (BMI 25-29.9 kg/m²), the Pro/Ala genotype was associated with greater BMI (P = 0.02), waist-to-hip ratio (P = 0.01), and waist circumference (P = 0.04). Among obese individuals, there was no association between any of the diabetes- or obesity-related traits and the Prol2Ala PPAR-γ2 variant. We conclude that among nonobese African Americans, the Pro/Ala genotype is associated with markers of greater insulin sensitivity.
- Subjects
PEROXISOMES; INSULIN; GENES; AFRICAN Americans
- Publication
Diabetes, 2003, Vol 52, Issue 6, p1568
- ISSN
0012-1797
- Publication type
Article
- DOI
10.2337/diabetes.52.6.1568