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- Title
Uncoupling protein 3 is reduced in skeletal muscle of NIDDM patients.
- Authors
Krook, Anna; Dighy, Janet; O'Rahilly, Stephen; Zierath, Juleen R.; Wallberg-Henriksson, Harriet; Krook, A; Digby, J; O'Rahilly, S; Zierath, J R; Wallberg-Henriksson, H
- Abstract
Two recently described proteins in the mitochondrial uncoupling protein (UCP) family, UCP-2 and UCP-3, have been linked to phenotypes of obesity and NIDDM. We determined the mRNA levels of UCP-2 and UCP-3 in skeletal muscle of NIDDM patients and of healthy control subjects. No difference in the mRNA levels or in the protein expression of UCP-2 was observed between the two groups. In contrast, mRNA levels of UCP-3 were significantly reduced in skeletal muscle of NIDDM patients compared with control subjects. In the NIDDM patients, a positive correlation between UCP-3 expression and whole-body insulin-mediated glucose utilization rate was also noted. These results suggest that UCP-3 regulation may be altered in states of insulin resistance.
- Subjects
MUSCLE proteins; TYPE 2 diabetes; OBESITY
- Publication
Diabetes, 1998, Vol 47, Issue 9, p1528
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diabetes.47.9.1528