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- Title
Effect of Schisandra chinensis (Turcz) Schisandraceae seed extracts and cisplatin on cytotoxicity, genotoxicity and wound healing in MCF-7 cells.
- Authors
Liang-Mei Li; Jing Yang
- Abstract
Purpose: Schisandra chinensis is a plant used in traditional Chinese and Russian medicine. An S. chinensis seed extract was tested for its ability to potentiate the effects of the anticancer agent cisplatin in MCF-7 breast cancer cells. Methods: S. chinensis seeds were extracted with ethanol and the ethanol was evaporated from the extracts to obtain an aqueous fraction of the S. chinensis seed extract (SCSE). MCF-7 cells were exposed to cisplatin alone or in combination with various concentrations of SCSE. The end points that were measured were cytotoxicity, genotoxicity, and wound healing. Results: The addition of 10 % SCSE increased the cytotoxicity of cisplatin by increasing MCF-7 cell death by 7 %. The combination of 20 % SCSE and cisplatin completely inhibited wound healing in MCF- 7 cells. SCSE alone did not induce DNA fragmentation in MCF-7 cells. Conclusion: Compounds from S. chinensis seed extracts may mitigate cancer cell proliferation and migration.
- Subjects
SCHISANDRA chinensis; CELL-mediated cytotoxicity; GENETIC toxicology; WOUND healing; CISPLATIN
- Publication
Tropical Journal of Pharmaceutical Research, 2017, Vol 16, Issue 12, p2843
- ISSN
1596-5996
- Publication type
Article
- DOI
10.4314/tjpr.v16i12.7