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- Title
Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage.
- Authors
Scott, Gregory; Hellyer, Peter J; Ramlackhansingh, Anil F; Brooks, David J; Matthews, Paul M; Sharp, David J
- Abstract
<bold>Background: </bold>Traumatic brain injury can trigger chronic neuroinflammation, which may predispose to neurodegeneration. Animal models and human pathological studies demonstrate persistent inflammation in the thalamus associated with axonal injury, but this relationship has never been shown in vivo.<bold>Findings: </bold>Using [(11)C]-PK11195 positron emission tomography, a marker of microglial activation, we previously demonstrated thalamic inflammation up to 17 years after traumatic brain injury. Here, we use diffusion MRI to estimate axonal injury and show that thalamic inflammation is correlated with thalamo-cortical tract damage.<bold>Conclusions: </bold>These findings support a link between axonal damage and persistent inflammation after brain injury.
- Subjects
BRAIN metabolism; BRAIN; BRAIN injuries; CEREBRAL cortex; INFLAMMATION; RESEARCH funding; THALAMUS; NEURAL pathways
- Publication
Journal of Neuroinflammation, 2015, Vol 12, Issue 1, p224
- ISSN
1742-2094
- Publication type
journal article
- DOI
10.1186/s12974-015-0445-y