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- Title
Echocardiographic integrated backscatter for detecting progression and regression of aortic valve calcifications in rats.
- Authors
Iida, Keiichiro; Bala, Gezim; Gillis, Kris; Remory, Isabel; Droogmans, Steven; Somja, Joan; Delvenne, Eléonore; De Nayer, Joeri; Schiettecatte, Johan; Delvenne, Philippe; Lancellotti, Patrizio; Camp, Guy Van; Cosyns, Bernard
- Abstract
Background: Calcification is an independent predictor of mortality in calcific aortic valve disease (CAVD). The aim of this study was to evaluate the use of non-invasive, non-ionizing echocardiographic calibrated integrated backscatter (cIB) for monitoring progression and subsequent regression of aortic valvular calcifications in a rat model of reversible renal failure with CAVD, compared to histology. Methods: 28 male Wistar rats were prospectively followed during 21 weeks. Group 1 (N=14) was fed with a 0.5% adenine diet for 9 weeks to induce renal failure and CAVD. Group 2 (N=14) received a standard diet. At week 9, six animals of each group were killed. The remaining animals of group 1 (N=8) and group 2 (N=8) were kept on a standard diet for an additional 12 weeks. cIB of the aortic valve was calculated at baseline, 9 and 21 weeks, followed by measurement of the calcified area (Ca Area) on histology. Results: At week 9, cIB values and Ca Area of the aortic valve were significantly increased in the adenine-fed rats compared to baseline and controls. After 12 weeks of adenine diet cessation, cIB values and Ca Area of group 1 decreased compared to week 9, while there was no longer a significant difference compared to age-matched controls of group 2. Conclusions: cIB is a non-invasive tool allowing quantitative monitoring of CAVD progression and regression in a rat model of reversible renal failure, as validated by comparison with histology. This technique might become useful for assessing CAVD during targeted therapy.
- Subjects
ECHOCARDIOGRAPHY; BACKSCATTERING; AORTIC valve diseases; CALCIFICATION; LABORATORY rats; KIDNEY failure; ADENINE
- Publication
Cardiovascular Ultrasound, 2013, Vol 11, Issue 1, p1
- ISSN
1476-7120
- Publication type
Article
- DOI
10.1186/1476-7120-11-4