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- Title
The clinical value of ERCP-guided cholangiopancreatoscopy using a single-operator system.
- Authors
Reuterwall, Marcus; Lubbe, Jeanne; Enochsson, Lars; Lundell, Lars; Konradsson, Magnus; Swahn, Frederik; Del Chiaro, Marco; Löhr, Matthias; Arnelo, Urban
- Abstract
<bold>Background: </bold>Single-operator, per-oral cholangiopancreatoscopy (SOPCP) enables direct biliopancreatic ductal visualization, targeted tissue sampling, and therapeutic intervention. At Karolinska University Hospital, SOPCP was introduced early and has since been extensively utilized according to a standardized protocol. We analysed the clinical value of SOPCP in the diagnosis and treatment of biliopancreatic diseases in a single high volume center.<bold>Methods: </bold>All SOPCP procedures performed between March 2007 and December 2014 were retrospectively reviewed. Each procedure's diagnostic yield and therapeutic value was evaluated using a predefined 4 grade scale; 1 - no diagnostic or therapeutic value, 2 - information gained did not impact clinical decision-making and in case of a therapeutic intervention, did not alter the clinical course of the patient, 3 - information gained had an impact on clinical decision-making and in the case of a therapeutic intervention, assisted subsequent disease management, and finally, 4 - information gained was essential and critical for clinical decision-making and in case of a therapeutic intervention, solved the clinical problem requiring no further therapeutic actions. Descriptive statistics were used to analyse results, with uni- and multivariate analyses completed to assess risk of adverse events.<bold>Results: </bold>During the study period, 365 SOPCP procedures were performed. We found SOPCP of pivotal importance (grade 4) in 19% of cases, and of great clinical significance (grade 3) in 44% of cases. SOPCP did not affect clinical decision-making or alter clinical course (grade 1 and 2) in 37% of cases.<bold>Conclusion: </bold>SOPCP offers direct access to the biliopancreatic ducts for both diagnostic and therapeutic purposes, adding significant clinical value in 64% of cases.<bold>Trial Registration: </bold>As this is a purely observational and retrospectively registered study in which the assignment of the medical intervention was not at the discretion of the investigator, it has not been registered in a registry.
- Subjects
PANCREATIC duct; MULTIVARIATE analysis; BILE ducts; DISEASE management; DESCRIPTIVE statistics; ASSIGNMENT problems (Programming)
- Publication
BMC Gastroenterology, 2019, Vol 19, Issue 1, pN.PAG
- ISSN
1471-230X
- Publication type
journal article
- DOI
10.1186/s12876-019-0953-9