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- Title
Advances in management of hereditary medullary thyroid cancer.
- Authors
Machens A; Ukkat J; Brauckhoff M; Gimm O; Dralle H
- Abstract
This work draws on recent advances during the era of codon-oriented prophylactic surgery for hereditary medullary thyroid cancer (MTC). Milestones included identification of RET (REarranged during Transfection) as the susceptibility gene, introduction of prophylactic surgery on evidence of a RET germline mutation, revelation of genotype-phenotype correlations within the MEN 2 spectrum and demonstration of age-related progression of MTC. Novel surgical techniques, notably systemic microdissection and compartment-oriented surgery, have greatly enhanced surgical cure. Uncovering molecular pathways from RET genotype to MEN 2 phenotype should provide treatment options for RET mutation carriers whose MTC currently is too advanced for cure.
- Publication
Journal of Internal Medicine, 2005, Vol 257, Issue 1, p50
- ISSN
0954-6820
- Publication type
Journal Article
- DOI
10.1111/j.1365-2796.2004.01423.x