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- Title
Anti-polyribosylribitol phosphate antibody in pediatric patients with Haemophilus influenzae type b invasive disease.
- Authors
Ishiwada, Naruhiko; Honda, Yoshiko; Tanaka, Junko; Hishiki, Haruka; Kohno, Yoichi
- Abstract
Haemophilus influenzae type b conjugate vaccine was recently introduced to Japan for voluntary immunizations. H. influenzae type b remains a leading cause of pediatric invasive diseases in Japan. The purposes of this study were to verify the suitability of the H. influenzae type b conjugate vaccine for immunizing children with a history of invasive H. influenzae type b disease and to determine whether H. influenzae type b conjugate vaccine is immunogenic in these children. The subjects comprised 64 children with a history of invasive H. influenzae type b disease. Serum samples from 64 patients with H. influenzae type b systemic infection in the acute and convalescent phases were analyzed. Serum anti-polyribosylribitol phosphate antibody responses of patients <2 years old were poorer than those observed in patients ≥2 years old. Nineteen of the 64 patients received a single dose of H. influenzae serotype b conjugate vaccine, and then follow-up serum was taken and analyzed. Eighteen of 19 patients had ≥1 μg/mL of anti-polyribosylribitol phosphate antibody titer after the first dose of H. influenzae type b conjugate vaccine. H. influenzae type b conjugate vaccine is immunogenic in children with invasive H. influenzae type b disease. Children <4 years old, and particularly <2 years old, with invasive H. influenzae type b disease should receive subsequent immunization with a H. influenzae type b conjugate vaccine.
- Subjects
JAPAN; HAEMOPHILUS influenzae; VACCINES; IMMUNIZATION of children; IMMUNIZATION
- Publication
Journal of Infection & Chemotherapy (Springer Science & Business Media B.V.), 2011, Vol 17, Issue 3, p397
- ISSN
1341-321X
- Publication type
Article
- DOI
10.1007/s10156-010-0186-x