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- Title
Adult Still's disease associated with cytomegalovirus infection.
- Authors
Kinichi Izumikawa; Yoshitomo Morinaga; Akira Kondo; Kohei Hara; Koichi Izumikawa; Yoshitsugu Miyazaki; Shigeru Kohno; Narihiko Igari; Mana Akaboshi; Jun Kawakami; Katsumi Eguchi
- Abstract
Abstract A 77-year-old woman was admitted to our hospital complaining of high fever. The physical examination on admission indicated no abnormality. Although several antibiotics were administered, the spiking high fever was not alleviated. Two weeks after admission a macular rash appeared, and a high concentration of serum ferritin was observed. At this point, Still's disease was suspected, and the patient was referred to Nagasaki University Hospital. During the prescribed course of prednisolone, hepatic enzymes gradually increased to high titers accompanied by a positive test for cytomegalovirus (CMV) antigen. The CMV antigen disappeared after ganciclovir administration, and the concentration of serum ferritin decreased after steroid administration. In this report, we attempt to portray the relation between the pathogenesis of adult-onset Still's disease and the presence of CMV antigen.
- Subjects
RHEUMATOID arthritis; CYTOMEGALOVIRUS diseases; AUTOIMMUNE diseases; HERPESVIRUS diseases; HOSPITAL patients
- Publication
Journal of Infection & Chemotherapy (Springer Science & Business Media B.V.), 2007, Vol 13, Issue 2, p114
- ISSN
1341-321X
- Publication type
Article
- DOI
10.1007/s10156-007-0503-1