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- Title
Vascular space occupancy (VASO) cerebral blood volume-weighted MRI identifies hemodynamic impairment in patients with carotid artery disease.
- Authors
Donahue, Manus J.; Jan van Laar, Peter; van Zijl, Peter C.M.; Stevens, Robert D.; Hendrikse, Jeroen
- Abstract
Purpose To assess the role of vascular space occupancy (VASO) magnetic resonance imaging (MRI), a noninvasive cerebral blood volume (CBV)-weighted technique, for evaluating CBV reactivity in patients with internal carotid artery (ICA) stenosis. Materials and Methods VASO reactivity, defined as a signal change in response to hypercapnic stimulus (4-second exhale, 14-second breath-hold), was measured in the left and right ICA flow territories in patients ( n = 10) with varying degrees of unilateral and bilateral ICA stenosis and in healthy volunteers ( n = 10). Results Percent VASO reactivity was more negative ( P < 0.01) bilaterally in patients (ipsilateral: −3.6 ± 1.5%; contralateral: −3.4 ± 1.2%) compared with age-matched controls (left: −1.9 ± 0.6%; right: −1.9 ± 0.8%). Owing to the nature of the VASO contrast mechanism, this more negative VASO reactivity was attributed to autoregulatory CBV effects in patients. A postbreath-hold overshoot, which was absent in healthy volunteers, was observed unilaterally in a subset of patients. Conclusion More negative VASO reactivity was observed in patients with ICA stenosis and may be a marker of autoregulatory effects. Furthermore, the postbreath-hold overshoot observed in patients is consistent with compensatory microvascular vasoconstriction and may be a marker of hemodynamic impairment. Based on the results of this feasibility study, VASO should be useful for identifying CBV adjustments in patients with steno-occlusive disease of the ICA. J. Magn. Reson. Imaging 2009;29:718-724. © 2009 Wiley-Liss, Inc.
- Publication
Journal of Magnetic Resonance Imaging, 2009, Vol 29, Issue 3, p718
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.21667