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- Title
A Review on Generation and Reactivity of the N -Heterocyclic Carbene-Bound Alkynyl Acyl Azolium Intermediates.
- Authors
Dong, Ziyang; Jiang, Chengming; Zhao, Changgui
- Abstract
N-heterocyclic carbene (NHC) has been widely used as an organocatalyst for both umpolung and non-umpolung chemistry. Previous works mainly focus on species including Breslow intermediate, azolium enolate intermediate, homoenolate intermediate, alkenyl acyl azolium intermediate, etc. Notably, the NHC-bound alkynyl acyl azolium has emerged as an effective intermediate to access functionalized cyclic molecular skeleton until very recently. In this review, we summarized the generation and reactivity of the NHC-bound alkynyl acyl azolium intermediates, which covers the efforts and advances in the synthesis of achiral and axially chiral cyclic scaffolds via the NHC-bound alkynyl acyl azolium intermediates. In particular, the mechanism related to this intermediate is discussed in detail.
- Subjects
UMPOLUNG; SKELETON; ANNULATION; SPECIES
- Publication
Molecules, 2022, Vol 27, Issue 22, p7990
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27227990