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- Title
Alcohols as Substrates and Solvents for the Construction of 3-Alkoxylated-2-Oxindoles by Direct Alkoxylation of 3-Halooxindoles.
- Authors
Bing Lin; Zhi-Yong Chen; Huan-Huan Liu; Qi-Di Wei; Ting-Ting Feng; Ying Zhou; Can Wang; Xiong-Li Liu; Wei-Cheng Yuan
- Abstract
Described herein is an environmentally benign method for the synthesis of multisubstituted 3-alkoxylated-2-oxindoles 3 via direct alkoxylation of 3-halooxindoles 1. A wide variety of such multisubstituted 3-alkoxylated-2-oxindole scaffolds were smoothly obtained in good yields (up to 94%) by heating in an oil bath at 35 °C for 24 h. A particularly valuable feature of this method was the development of environment-friendly chemistry using alcohols 2 as both the substrates and solvents in the presence of a catalytic amount of base.
- Publication
Molecules, 2017, Vol 22, Issue 5, p801
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules22050801