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- Title
Trithiocyanurate Complexes of Iron, Manganese and Nickel and Their Anticholinesterase Activity.
- Authors
Kopel, Pavel; Dolezal, Karel; Langer, Vratislav; Jun, Daniel; Adam, Vojtech; Kuca, Kamil; Kizek, Rene
- Abstract
The complexes of Fe(II), Mn(II) and Ni(II) with a combination of a Schiff base, nitrogen-donor ligand or macrocyclic ligand and trithiocyanuric acid (ttcH3) were prepared and characterized by elemental analysis and spectroscopies. Crystal and molecular structures of the iron complex of composition [Fe(L1)](ttcH2)(ClO4)∙EtOH∙H2O (1), where L1 is Schiff base derived from tris(2-aminoethyl)amine and 2-pyridinecarboxaldehyde, were solved. It was found that the Schiff base is coordinated to the central iron atom by six nitrogens forming deformed octahedral arrangement, whereas trithiocyanurate(1-) anion, perchlorate and solvent molecules are not coordinated. The X-ray structure of the Schiff base sodium salt is also presented and compared with the iron complex. The anticholinesterase activity of the complexes was also studied.
- Subjects
CHOLINESTERASE inhibitors; MACROCYCLIC compounds; SCHIFF bases; CRYSTAL structure; ACETYLCHOLINESTERASE; TOXOPLASMA gondii; TOXOPLASMOSIS
- Publication
Molecules, 2014, Vol 19, Issue 4, p4338
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules19044338