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- Title
Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses.
- Authors
Nohara, Tomohiro; Imamura, Akihiro; Yamaguchi, Maho; Hidari, Kazuya I. P. J.; Suzuki, Takashi; Komori, Tatsuya; Ando, Hiromune; Ishida, Hideharu; Kiso, Makoto
- Abstract
A novel ganglioside bearing Neuα2-3Gal and Neuα2-6Gal structures as distal sequences was designed as a ligand for influenza A viruses. The efficient synthesis of the designed ganglioside was accomplished by employing the cassette coupling approach as a key reaction, which was executed between the non-reducing end of the oligosaccharide and the cyclic glucosylceramide moiety. Examination of its binding activity to influenza A viruses revealed that the new ligand is recognized by Neuα2-3 and 2-6 type viruses.
- Subjects
GANGLIOSIDES; INFLUENZA A virus; OLIGOSACCHARIDES; GLUCOSYLCERAMIDES; LIGANDS (Biochemistry)
- Publication
Molecules, 2012, Vol 17, Issue 8, p9590
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules17089590