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- Title
Characterization of Epstein-Barr virus gp350/220 gene variants in virus isolates from gastric carcinoma and nasopharyngeal carcinoma.
- Authors
Luo, Bing; Liu, Mengyang; Chao, Yan; Wang, Yun; Jing, Yongzheng; Sun, Zhifu
- Abstract
To characterize the sequence variation of the gp350/220 and explore its potential association with EBV-associated tumors, the gp350/220 gene was sequenced from 41 EBV-associated gastric carcinoma (EBVaGC) and 81 nasopharyngeal carcinoma (NPC) biopsies as well as 35 throat washing (TW) samples from healthy donors. Preferential linkages between variants of the N-terminus of gp350/220 and EBNA3C variants were detected, and type A/BLLF1-a was the dominant variant in this study. The dominant variant in the C-terminal region of gp350/220 was 9P. The similar distribution of gp350/220 variants in NPC, EBVaGC and healthy donors suggest that gp350/220 variations are geographically restricted rather than tumor-specific polymorphisms.
- Subjects
EPSTEIN-Barr virus; STOMACH cancer; NASOPHARYNX cancer; GENETIC polymorphisms; BIOPSY; HERPESVIRUSES; FIBRINOGEN polymorphisms
- Publication
Archives of Virology, 2012, Vol 157, Issue 2, p207
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-011-1148-z