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- Title
Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L.
- Authors
Safonova, E. A.; Lopatina, K. A.; Razina, T. G.; Zueva, E. P.; Fedorova, E. P.; Gur'ev, A. M.; Belousov, M. V.
- Abstract
The experiments on C57Bl/6 mice with Lewis lung carcinoma showed that addition of Tussilago farfara L. polysaccharides to conventional cisplatin/paclitaxel polychemotherapy moderated neutropenia caused by antitumor therapy and increased its efficiency. The stimulating effect of polysaccharides on the granulopoietic lineage cells is comparable with that of recombinant CSF Neupogen.
- Subjects
POLYSACCHARIDES; COMBINATION drug therapy; TUSSILAGO farfara; CISPLATIN; BONE marrow
- Publication
Bulletin of Experimental Biology & Medicine, 2018, Vol 166, Issue 2, p197
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-018-4313-5