We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Cell Reconstruction of the Rectal Mucosa in Patients with Familial Adenomatous Polyposis: Endoscopy, Morphology, Immunohistochemistry.
- Authors
Kogan, E.; Vyshegorodtsev, D.; Faizullina, N.; Demura, T.; Kuz'minov, A.; Shelygin, Yu.; Sukhikh, G.
- Abstract
We propose a new surgical approach to the treatment of familial colorectal adenomatous polyposis implying preservation of a portion of the rectum with removed mucosa. For reconstruction of the rectum, allotransplantation of the mixed culture of fetal allogenic somatic cells of the intestinal epithelium and mesenchymal cells of various origin is used. The mechanisms of mucosa reparation were studied in 34 patients. Endoscopic, morphological, and immunohistochemical studies showed that cell transplantation considerably accelerated reparation of the mucosa in mucosectomized rectum. The proposed treatment of familial colorectal adenomatous polyposis allows delaying the development of rectal polyps and cancer for many years.
- Subjects
MUCOUS membranes; ADENOMATOUS polyposis coli; MORPHOLOGY; IMMUNOHISTOCHEMISTRY; POLYPS
- Publication
Bulletin of Experimental Biology & Medicine, 2014, Vol 157, Issue 5, p683
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-014-2643-5