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- Title
Genotoxic effects of pesticide fipronil in somatic and generative cells of mice.
- Authors
Lovinskaya, A.; Kolumbayeva, S.; Kolomiets, O.; Abilev, S.
- Abstract
The pronounced genotoxic effect of fipronil in all used doses (4.75, 9.50, 19.00, and 31.70 mg/kg) at a single exposure in the liver, lungs and spleen was ascertained by the Comet assay. Organ specificity of genotoxic effects of the pesticide was revealed. The liver was the most sensitive to fipronil. Fipronil at a dose of 9.50 mg/kg in a single and repeated exposure (within 10 days) induced aberrations in mouse bone marrow cells with the frequency exceeding the spontaneous mutation rate ( p < 0.01 and p < 0.001, respectively). Fipronil also showed genotoxic activity in the germ cells of the experimental animals, causing abnormalities of the structure of synaptonemal complexes in the spermatocytes.
- Subjects
PESTICIDE toxicology; FIPRONIL; SOMATIC cells; TISSUE-specific antigens; CHROMOSOME abnormalities; SYNAPTONEMAL complexes; LABORATORY mice
- Publication
Russian Journal of Genetics, 2016, Vol 52, Issue 5, p491
- ISSN
1022-7954
- Publication type
Article
- DOI
10.1134/S1022795416050070