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- Title
Porous Polylactide Microparticles as Effective Fillers for Hydrogels.
- Authors
Zagoskin, Yuriy D.; Sergeeva, Yana E.; Fomina, Yuliya S.; Sukhinov, Daniil V.; Malakhov, Sergey N.; Osidak, Egor O.; Khramtsova, Elena A.; Gotovtsev, Pavel M.; Chvalun, Sergei N.; Grigoriev, Timofei E.
- Abstract
High-strength composite hydrogels based on collagen or chitosan–genipin were obtained via mixing using highly porous polylactide (PLA) microparticles with diameters of 50–75 µm and porosity values of over 98%. The elastic modulus of hydrogels depended on the filler concentration. The modulus increased from 80 kPa to 400–600 kPa at a concentration of porous particles of 12–15 wt.% and up to 1.8 MPa at a filling of 20–25 wt.% for collagen hydrogels. The elastic modulus of the chitosan–genipin hydrogel increases from 75 kPa to 900 kPa at a fraction of particles of 20 wt.%. These elastic modulus values cover a range of strength properties from connective tissue to cartilage tissue. It is important to note that the increase in strength in this case is accompanied by a decrease in the density of the material, that is, an increase in porosity. PLA particles were loaded with C-phycocyanin and showed an advanced release profile up to 48 h. Thus, composite hydrogels mimic the structure, biomechanics and release of biomolecules in the tissues of a living organism.
- Subjects
POLYLACTIC acid; CONNECTIVE tissues; HYDROGELS; ELASTIC modulus; ACOUSTIC microscopy; POROUS materials
- Publication
Biomimetics (2313-7673), 2023, Vol 8, Issue 8, p565
- ISSN
2313-7673
- Publication type
Article
- DOI
10.3390/biomimetics8080565