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- Title
Long non-coding RNA SOX2OT in tamoxifen-resistant breast cancer.
- Authors
Lee, Jeeyeon; Kim, Eun-Ae; Kang, Jieun; Chae, Yee Soo; Park, Ho Yong; Kang, Byeongju; Lee, Soo Jung; Lee, In Hee; Park, Ji-Young; Park, Nora Jee-young; Jung, Jin Hyang
- Abstract
Hormone receptor (HR)-positive breast cancer can become aggressive after developing hormone-treatment resistance. This study elucidated the role of long non-coding RNA (lncRNA) SOX2OT in tamoxifen-resistant (TAMR) breast cancer and its potential interplay with the tumor microenvironment (TME). TAMR breast cancer cell lines TAMR-V and TAMR-H were compared with the luminal type A cell line (MCF-7). LncRNA expression was assessed via next-generation sequencing, RNA extraction, lncRNA profiling, and quantitative RT-qPCR. SOX2OT overexpression effects on cell proliferation, migration, and invasion were evaluated using various assays. SOX2OT was consistently downregulated in TAMR cell lines and TAMR breast cancer tissue. Overexpression of SOX2OT in TAMR cells increased cell proliferation and cell invasion. However, SOX2OT overexpression did not significantly alter SOX2 levels, suggesting an independent interaction within TAMR cells. Kaplan–Meier plot analysis revealed an inverse relationship between SOX2OT expression and prognosis in luminal A and B breast cancers. Our findings highlight the potential role of SOX2OT in TAMR breast cancer progression. The downregulation of SOX2OT in TAMR breast cancer indicates its involvement in resistance mechanisms. Further studies should explore the intricate interactions between SOX2OT, SOX2, and TME in breast cancer subtypes.
- Subjects
LINCRNA; BREAST cancer; HORMONE receptors; GENE expression; NUCLEOTIDE sequencing
- Publication
BMC Molecular & Cell Biology, 2024, Vol 25, Issue 1, p1
- ISSN
2661-8850
- Publication type
Article
- DOI
10.1186/s12860-024-00510-y