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- Title
Genetic control of parasite clearance leads to resistance to Plasmodium berghei ANKA infection and confers immunity.
- Authors
Campino, S.; Bagot, S.; Bergman, M.-L.; Almeida, P.; Sepúlveda, N.; Pied, S.; Penha-Gonçalves, C.; Holmberg, D.; Cazenave, P.-A.
- Abstract
Unprecedented cure after infection with the lethal Plasmodium berghei ANKA was observed in an F2 progeny generated by intercrossing the wild-derived WLA and the laboratory C57BL/6 mouse strains. Resistant mice were able to clear parasitaemia and establish immunity. The observed resistance was disclosed as a combinatorial effect of genetic factors derived from the two parental strains. Genetic mapping of survival time showed that the WLA allele at a locus on chromosome 1 (colocalizing with Berghei resistance 1 (Berr1), a locus associated with resistance to experimental cerebral malaria) increases the probability to resist early death. Also, the C57Bl/6 allele at a novel locus on chromosome 9 (Berr3) confers overall resistance to this lethal Plasmodium infection. This report underlines the value of using wild-derived mouse strains to identify novel genetic factors in the aetiology of disease phenotypes, and provides a unique model for studying parasite clearance and immunity associated with malaria.Genes and Immunity (2005) 6, 416–421. doi:10.1038/sj.gene.6364219; published online 23 June 2005
- Subjects
PLASMODIUM; LABORATORY mice; GENE mapping; CHROMOSOMES; IMMUNITY; GENETICS
- Publication
Genes & Immunity, 2005, Vol 6, Issue 5, p416
- ISSN
1466-4879
- Publication type
Article
- DOI
10.1038/sj.gene.6364219