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- Title
Real-World Outcomes of Belantamab Mafodotin for Relapsed/Refractory Multiple Myeloma (RRMM): Preliminary Results of a Spanish Expanded Access Program (EAP).
- Authors
Alegre, Adrián; Benzo, Gonzalo; Alonso, Rafael; Martínez-López, Joaquín; Jimenez-Ubieto, Ana; Cuéllar, Clara; Askari, Elham; Prieto, Elena; Aláez, Concepción; Aguado, Beatriz; Velasco, Alberto; Krsnik, Isabel; Bocanegra, Ana; Llorente, Laura; Muñoz-Linares, Cristina; Morales, Ana; Giménez, Eugenio; Iglesias, Rebeca; Martínez-Chamorro, Carmen; Alonso, Aránzazu
- Abstract
Introduction: Belantamab mafodotin (BM) is a new anti-BCMA antibody–drug conjugate, recently approved for triple-class relapsed and refractory multiple myeloma (RRMM). We assessed real-world outcomes with BM in patients under the Spanish Expanded Access Program (EAP). Methods: We conducted an observational, retrospective, multicenter study including RRMM patients who received ≥ 1 dose of BM (Nov 2019 to Jun 2021). The primary endpoint was overall response rate (ORR). Secondary endpoints were progression-free survival (PFS), overall survival (OS), and incidence of treatment-emergent adverse events (TEAEs). Results: Thirty-three patients were included with a median of 70 years of age (range, 46–79 years). Median time from diagnosis was 71 months (range, 10–858 months). Median prior lines was 5 (range, 3–8 lines); 90% of patients were triple-/quad-/penta-refractory; 48% showed high-risk cytogenetics. Median BM doses was 3 (range 1–16 doses), with a median follow-up of 11 months (6–15 months). ORR was 42.2% (≥ VGPR, 18.2%). Median PFS was 3 months (95% CI 0.92–5.08) in the overall population, and 11 months (HR 0.26; 95% CI 0.10–0.68) for patients who achieved ≥ PR. PFS was not significantly different according to age, cytogenetic risk, and prior therapy lines. OS was 424 days (95% CI 107–740). Non-hematological TEAEs (57.6% of patients; 30.3% ≥ G3) included keratopathy (51.5%; 21.2% ≥ G3) and patient-reported vision-related symptoms (45.5%). Keratopathy was resolved in 70.6% of patients. G3 hematological TEAEs was 18.2%, thrombocytopenia (21.2%). Dose reductions due to TEAEs: 30.3%; delays: 36.4%. Treatment discontinuation causes: progression (54.5%), toxicity (non-ocular; 6%/ocular; 6% /ocular + non-ocular toxicity; 3%), death (6%), and patient's decision (3%). Conclusions: BM showed relevant anti-myeloma activity in RRMM with a manageable safety profile. These results corroborate those observed in the BM pivotal trial.
- Subjects
SPAIN; THERAPEUTIC use of monoclonal antibodies; THERAPEUTIC use of antineoplastic agents; RESEARCH; DRUG efficacy; SCIENTIFIC observation; CONFIDENCE intervals; RETROSPECTIVE studies; TREATMENT effectiveness; DISEASE relapse; DESCRIPTIVE statistics; MULTIPLE myeloma; PROGRESSION-free survival; PATIENT safety; EVALUATION
- Publication
Oncology & Therapy, 2023, Vol 11, Issue 1, p83
- ISSN
2366-1070
- Publication type
Article
- DOI
10.1007/s40487-022-00212-5