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- Title
CLINICAL AND IMMUNOLOGICAL CORRELATIONS IN PATIENTS WITH ANTIPHOSPHOLIPID SYNDROME.
- Authors
STOILOV, N.; BOYADZHIEVA, VL.; RASHKOV, R.; STEFANOV, S.; MARINOV, B.; VLADIMIROV, V.
- Abstract
Antiphospholipid syndrome (APS) is an autoimmune, multisystem disorder characterised by thrombocytopenia, venous and/or arterial thrombosis, pathological course of pregnancy in women in the presence of a heterogeneous group of antibodies - antiphospholipid antibodies (aPL). Our aim is to evaluate the correlation between aPL, antinuclear antibodies (ANA) and clinical manifestations in patients with APS. Patients were tested for the aPL directed against cardiolipin (aCL), β2glikoprotein1 (anti-β2GPI) and prothrombin (anti-prothrombin), by the method of ELISA. In our group, secondary APS is 87.5% and primary is 12.5%. Patients with positive aCL are 85.3%, β2GPI - 74.3% and 3.7% for anti-prothrombin. The secondary APS is in the context of: SLE - 74.2%, RA - 8.8%, vasculitis - 8.8%, others - 8.2%. The Pearson analysis establishes strong, statistically significant positive correlation between: aCL and β2GPI, β2GPI and anti-M2, anti-Scl70, anti- RibP, β2GPI/aCL and anti-M2. Most often positive aPL is for aCL, followed by anti- β2GPI and most frequently anti-protrombin. In half of the patients with complicated pregnancies is found the coexistence of aCL and anti-β2GPI. In the conducted correlation analysis showed a statistically significant association between miscarriage and the presence of anti-β2GPI. Severity of clinical manifestations of APS correlates directly proportional to the titer and number of aPL.
- Subjects
ANTIPHOSPHOLIPID syndrome; ANTIPHOSPHOLIPID syndrome treatment; AUTOIMMUNE diseases; ATHEROSCLEROSIS; ATHEROSCLEROSIS treatment; PHYSIOLOGY; DIAGNOSIS
- Publication
Oxidation Communications, 2016, Vol 39, Issue 1-I, p204
- ISSN
0209-4541
- Publication type
Article