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- Title
A Vaccine Displaying a Trimeric Influenza-A HA Stem Protein on Capsid-Like Particles Elicits Potent and Long-Lasting Protection in Mice.
- Authors
Thrane, Susan; Aves, Kara-Lee; Uddbäck, Ida E. M; Janitzek, Christoph M.; Han, Julianna; Yang, Yuhe R.; Ward, Andrew B.; Theander, Thor G.; Nielsen, Morten A.; Salanti, Ali; Thomsen, Allan R.; Christensen, Jan P.; Sander, Adam F.
- Abstract
Due to constant antigenic drift and shift, current influenza-A vaccines need to be redesigned and administered annually. A universal flu vaccine (UFV) that provides long-lasting protection against both seasonal and emerging pandemic influenza strains is thus urgently needed. The hemagglutinin (HA) stem antigen is a promising target for such a vaccine as it contains neutralizing epitopes, known to induce cross-protective IgG responses against a wide variety of influenza subtypes. In this study, we describe the development of a UFV candidate consisting of a HAstem trimer displayed on the surface of rigid capsid-like particles (CLP). Compared to soluble unconjugated HAstem trimer, the CLP-HAstem particles induced a more potent, long-lasting immune response and were able to protect mice against both homologous and heterologous H1N1 influenza challenge, even after a single dose.
- Subjects
H1N1 influenza; INFLUENZA vaccines; VACCINES; PARTICLES; MICE
- Publication
Vaccines, 2020, Vol 8, Issue 3, p389
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines8030389