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- Title
Effect of minoxidil formulations on human scalp skin xenotransplants on SCID mice: A novel pre‐clinical in vivo assay for androgenetic alopecia research.
- Authors
Gilhar, Amos; Keren, Aviad; Ullmann, Yehuda; Wu, Jeff; Paus, Ralf
- Abstract
This was further corroborated by quantitative immunohistomorphometry, which showed that topical minoxidil significantly increased hair matrix cell proliferation (Ki-67) (Figure 1K-O) and decreased apoptosis (TUNEL) compared with pre-transplanted AGA scalp skin and vehicle (Figure 1K-O). Male pattern balding (androgenetic alopecia [AGA]) is the most common heritable, androgen-dependent cause of hair loss.1 AGA shows a distinctive clinical and histological phenotype characterized by the gradual conversion of terminal hair follicles (HFs) into vellus HFs along with anagen shortening and telogen prolongation. Evidence from a humanized mouse model of androgenetic alopecia that platelet-rich plasma stimulates hair regrowth, hair shaft diameter and vellus-to-terminal hair reconversion in vivo.
- Subjects
MINOXIDIL; SEVERE combined immunodeficiency; SCALP; XENOGRAFTS; HEART failure; BALDNESS
- Publication
Experimental Dermatology, 2022, Vol 31, Issue 6, p980
- ISSN
0906-6705
- Publication type
Article
- DOI
10.1111/exd.14523