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- Title
Placental 11β-HSD2 and Cardiometabolic Health Indicators in Infancy.
- Authors
Lu Chen; Guilmette, Julie; Zhong-Cheng Luo; Cloutier, Anik; Wen-Juan Wang; Meng-Nan Yang; Fraser, William D.; Dubois, Josée; Nuyt, Anne Monique; Chen, Lu; Luo, Zhong-Cheng; Wang, Wen-Juan; Yang, Meng-Nan
- Abstract
<bold>Objective: </bold>Fetal excessive exposure to glucocorticoids may program cardiometabolic risk. Placental 11 β-hydroxysteroid dehydrogenase 2 (11β-HSD2) serves as a barrier to prevent fetal overexposure to maternal glucocorticoids. It has not been explored whether placental 11β-HSD2 levels are associated with cardiometabolic health in postnatal life.<bold>Research Design and Methods: </bold>In a prospective birth cohort study of 246 mother-infant pairs, we measured placental 11β-HSD2 expression and maternal (32-35 weeks of gestation) and cord plasma cortisol concentrations. The primary outcomes were HOMA of insulin resistance (IR) and blood pressure (BP) in infants at age 1 year. Other outcomes included fasting insulin, HOMA β-cell function, carotid intima-media thickness, weight z score, and skinfold thickness (triceps and subscapular) at age 1 year.<bold>Results: </bold>Placental 11β-HSD2 expression was negatively correlated with HOMA-IR (r = -0.17, P = 0.021) and fasting insulin (r = -0.18, P = 0.017) and marginally negatively correlated with systolic BP (r = -0.16, P = 0.057) but was not correlated with HOMA of β-cell function, diastolic BP, carotid intima-media thickness, and skinfold thickness (all P > 0.1) in infants at age 1 year. Cord plasma cortisol was negatively correlated to skinfold thickness (r = -0.20, P = 0007) but was not correlated with other outcomes at age 1 year. Maternal plasma cortisol was positively correlated with maximal carotid intima-media thickness (r = 0.20, P = 0.03) but was not correlated with other outcomes. Adjusting for maternal and infant characteristics, the associations were similar.<bold>Conclusions: </bold>The study is the first to show that higher placental 11β-HSD2 expression is associated with lower IR in infancy. Independent cohort studies are required to confirm this novel finding.
- Subjects
CORTISONE; HEALTH status indicators; INFANTS; SKINFOLD thickness; BLOOD pressure; COHORT analysis
- Publication
Diabetes Care, 2019, Vol 42, Issue 5, p964
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc18-2041