We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Design, Synthesis, and Antifungal Activities of New β-Methoxyacrylate Analogues.
- Authors
Liu, Hui-Jun; Zhang, Xiang; Gao, Yong-Xin; Li, Jian-Zhong; Wang, Hui-Li
- Abstract
Strobilurins have become one of the most important classes of agricultural fungicides. To search for new strobilurin derivatives with high activity against resistant pathogens, a series of new β-methoxyacrylate analogues containing substituted pyrimidine in the side chain with strobilurin pharmacophore were synthesized and their biological activities were tested. The compounds were confirmed and characterized by 1H-NMR, elemental analysis and mass spectroscopy. The bioassays indicated that most of the compounds 1 exhibited potent antifungal activities against Colletotrichum orbiculare, Botrytis cinerea Pers and Phytophthora capsici Leonian at a concentration of 50 μg mL−1. Notably, compound 1b (R = 2,5-dimethylphenyl) showed better antifungal activity against all the tested fungi than the commercial strobilurin fungicide azoxystrobin.
- Subjects
ANTIFUNGAL agents; STROBILURINS; FUNGICIDES; BOTRYTIS cinerea; MASS spectrometry
- Publication
Journal of the Chinese Chemical Society, 2013, Vol 60, Issue 1, p27
- ISSN
0009-4536
- Publication type
Article
- DOI
10.1002/jccs.201200295