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- Title
Pharmacokinetics and bioavailability of flumequine in blunt snout bream ( Megalobrama amblycephala) after intravascular and oral administrations.
- Authors
Xu, N.; Dong, J.; Yang, Y.; Yang, Q.; Liu, Y.; Ai, X.
- Abstract
In this study, the pharmacokinetic profile of flumequine ( FMQ) was investigated in blunt snout bream ( Megalobrama amblycephala) after intravascular (3 mg/kg body weight (b.w.)) and oral (50 mg/kg b.w.) administrations. The plasma samples were determinedby ultra-performance liquid chromatography ( UPLC) with fluorescence detection. After intravascular administration, plasma concentration-time curves were best described by a two-compartment open model. The distribution half-life (t1/2 α), elimination half-life (t1/2 β), and area under the concentration-time curve ( AUC) of blunt snout bream were 0.6 h, 25.0 h, and 10612.7 h·μg/L, respectively. After oral administration, a two-compartment open model with first-order absorption was also best fit the data of plasma. The t1/2 α, t1/2 β, peak concentration (Cmax), time-to-peak concentration (Tmax), and AUC of blunt snout bream were estimated to be 2.5 h, 19.7 h, 3946.5 μg/L, 1.4 h, and 56618.1 h. μg/L, respectively. The oral bioavailability (F) was 32.0%. The pharmacokinetics of FMQ in blunt snout bream displayed low bioavailability, rapid absorption, and rapid elimination.
- Subjects
PHARMACOKINETICS; DRUG metabolism; BIOAVAILABILITY; SEBASTES marinus; SEBASTES
- Publication
Journal of Veterinary Pharmacology & Therapeutics, 2016, Vol 39, Issue 2, p191
- ISSN
0140-7783
- Publication type
Article
- DOI
10.1111/jvp.12261