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- Title
Statin Use and Influenza Vaccine Effectiveness in Persons >65 Years of Age, Taiwan.
- Authors
Lung-Wen Tsai; Yung-Tai Chen; Chia-Jen Shih; Shuo-Ming Ou; Pei-Wen Chao; Shih-Hsiu Lo; Tsai, Lung-Wen; Chen, Yung-Tai; Shih, Chia-Jen; Ou, Shuo-Ming; Chao, Pei-Wen; Lo, Shih-Hsiu
- Abstract
Debates on whether statin use reduces the effectiveness of influenza vaccines against critical illness and death among persons >65 years of age continue. We conducted a study of 9,427,392 persons >65 years of age who did and did not receive influenza vaccinations during 12 consecutive influenza seasons, 2000-01 through 2011-12. Using data from Taiwan's National Health Insurance Research Database, we performed propensity score-matching to compare vaccinated persons with unvaccinated controls. After propensity score-matching, the vaccinated group had lower risks for in-hospital death from influenza and pneumonia and for hospitalization for pneumonia and influenza, circulatory conditions, and critical illnesses compared with the unvaccinated group. We stratified the 2 groups by statin use and analyzed data by interaction analysis and saw no statistically significant difference. We found that influenza vaccine effectively reduced risks for hospitalization and death in persons >65 years of age, regardless of statin use.
- Subjects
TAIWAN; VACCINE effectiveness; INFLUENZA vaccines; CRITICALLY ill; INFLUENZA
- Publication
Emerging Infectious Diseases, 2020, Vol 26, Issue 6, p1243
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2606.190646