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- Title
Genomic Insight into the Spread of Meropenem-Resistant Streptococcus pneumoniae Spain<sup>23F</sup>-ST81, Taiwan.
- Authors
Yi-Yin Chen; Yu-Chia Hsieh; Yu-Nong Gong; Wei-Chao Liao; Shiao-Wen Li; Ian Yi-Feng Chang; Tzu-Lung Lin; Ching-Tai Huang; Cheng-Hsiu Chiu; Tsu-Lan Wu; Lin-Hui Su; Ting-Hsuan Li; Ya-Yu Huang; Chen, Yi-Yin; Hsieh, Yu-Chia; Gong, Yu-Nong; Liao, Wei-Chao; Li, Shiao-Wen; Chang, Ian Yi-Feng; Lin, Tzu-Lung
- Abstract
Incidence of invasive pneumococcal disease caused by antimicrobial-resistant Streptococcus pneumoniae types not included in pneumococcal conjugate vaccines has increased, including a penicillin- and meropenem-resistant serotype 15A-ST63 clone in Japan. During 2013-2017, we collected 206 invasive pneumococcal isolates in Taiwan for penicillin and meropenem susceptibility testing. We found serotypes 15B/C-ST83 and 15A-ST63 were the most prevalent penicillin- and meropenem-resistant clones. A transformation study confirmed that penicillin-binding protein (PBP) 2b was the primary meropenem resistance determinant, and PBP1a was essential for high-level resistance. The rate of serotype 15B/C-ST83 increased during the study. All 15B/C-ST83 isolates showed an ermB macrolide resistance genotype. Prediction analysis of recombination sites revealed 12 recombination regions in 15B/C-ST83 compared with the S. pneumoniae Spain23F-ST81 genome. Pneumococcal clones rapidly recombine to acquire survival advantages and undergo local expansion under the selective pressure exerted by vaccines and antimicrobial drugs. The spread of 15B/C-ST83 is alarming for countries with high antimicrobial pressure.
- Subjects
TAIWAN; STREPTOCOCCUS pneumoniae; PNEUMOCOCCAL vaccines; ANTI-infective agents; PENICILLIN-binding proteins; DRUG resistance in microorganisms
- Publication
Emerging Infectious Diseases, 2020, Vol 26, Issue 4, p711
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2604.190717