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- Title
Experimental Infection and Response to Rechallenge of Alpacas with Middle East Respiratory Syndrome Coronavirus.
- Authors
Crameri, Gary; Durr, Peter A.; Klein, Reuben; Foord, Adam; Meng Yu; Riddell, Sarah; Haining, Jessica; Johnson, Dayna; Hemida, Maged G.; Barr, Jennifer; Peiris, Malik; Middleton, Deborah; Lin-Fa Wang; Yu, Meng; Wang, Lin-Fa
- Abstract
We conducted a challenge/rechallenge trial in which 3 alpacas were infected with Middle East respiratory syndrome coronavirus. The alpacas shed virus at challenge but were refractory to further shedding at rechallenge on day 21. The trial indicates that alpacas may be suitable models for infection and shedding dynamics of this virus.
- Subjects
ALPACA; MIDDLE East respiratory syndrome transmission; ANIMAL disease models; MIDDLE East respiratory syndrome; VIRAL vaccines; PUBLIC health; PREVENTION; VACCINATION; ANIMAL experimentation; BIOLOGICAL models; COMPARATIVE studies; CORONAVIRUS diseases; IMMUNOGLOBULINS; MAMMALS; RESEARCH methodology; MEDICAL cooperation; RESEARCH; VIRAL antibodies; VIRAL physiology; VIRAL load; EVALUATION research; NEUTRALIZATION tests; MERS coronavirus
- Publication
Emerging Infectious Diseases, 2016, Vol 22, Issue 6, p1071
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2206.160007