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- Title
Cefepime-Resistant Pseudomonas aeruginosa.
- Authors
Akhabue, Ehimare; Synnestvedt, Marie; Weiner, Mark G.; Bilker, Warren B.; Lautenbach, Ebbing
- Abstract
Resistance to extended-spectrum cephalosporins complicates treatment of Pseudomonas aeruginosa infections. To elucidate risk factors for cefepime-resistant P. aeruginosa and determine its association with patient death, we conducted a case-control study in Philadelphia, Pennsylvania. Among 2,529 patients hospitalized during 2001-2006, a total of 213 (8.4%) had cefepime-resistant P. aeruginosa infection. Independent risk factors were prior use of an extended-spectrum cephalosphorin (p<0.001), prior use of an extended-spectrum penicillin (p = 0.005), prior use of a quinolone (p<0.001), and transfer from an outside facility (p = 0.01). Among those hospitalized at least 30 days, mortality rates were higher for those with cefepime-resistant than with cefepime-susceptible P. aeruginosa infection (20.2% vs. 13.2%, p = 0.007). Cefepime-resistant P. aeruginosa was an independent risk factor for death only for patients for whom it could be isolated from blood (p = 0.001). Strategies to counter its emergence should focus on optimizing use of antipseudomonal drugs.
- Subjects
PHILADELPHIA (Pa.); PENNSYLVANIA; CEPHALOSPORINS; PSEUDOMONAS aeruginosa infections; PSEUDOMONAS aeruginosa; CASE-control method; THERAPEUTICS
- Publication
Emerging Infectious Diseases, 2011, Vol 17, Issue 6, p1037
- ISSN
1080-6040
- Publication type
Article
- DOI
10.3201/eid1706.100358