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- Title
Active Cytomegalovirus Infection in Patients with Septic Shock.
- Authors
Von Müller, Lutz; Klemm, Anke; Weiss, Manfred; Schneider, Marion; Suger-Wiedeck, Heide; Durmus, Nilgün; Hampl, Walter; Mertens, Thomas
- Abstract
Cytomegalovirus (CMV) is a pathogen of emerging importance for patients with septic shock. In this prospective study, 25 immunocompetent CMV-seropositive patients with septic shock and an intensive care unit stay of >7 days were monitored by using quantitative pp65-antigenemia assay, shell vial culture, and virus isolation. Within 2 weeks, active CMV infection with low-level pp65-antigenemia (median 3 positive/5x105 leukocytes) developed in 8 (32%) patients. Infection was controlled within a few weeks (median 26 days) without use of antiviral therapy. Duration of intensive care and mechanical ventilation were significantly prolonged in patients with active CMV infection. CMV reactivation was associated with concomitant herpes simplex virus reactivation (p = 0.004). The association between active CMV infection and increased illness could open new therapeutic options for patients with septic shock. Future interventional studies are required.
- Subjects
CYTOMEGALOVIRUS diseases; SEPTIC shock; INTENSIVE care units; ANTIVIRAL agents; LEUCOCYTES
- Publication
Emerging Infectious Diseases, 2006, Vol 12, Issue 10, p1517
- ISSN
1080-6040
- Publication type
Article
- DOI
10.3201/eid1210.060411