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- Title
Thyroid autoimmunity and dysfunction in multiple sclerosis patients during long-term treatment with interferon beta or glatiramer acetate: an Italian multicenter study.
- Authors
Frisullo, Giovanni; Calabrese, Massimiliano; Tortorella, Carla; Paolicelli, Damiano; Ragonese, Paolo; Annovazzi, Pietro; Radaelli, Marta; Malucchi, Simona; Gallo, Antonio; Tomassini, Valentina; Nociti, Viviana; D’Onghia, Mariangela; Lo Re, Vincenzina; Rodegher, Mariemma; Solaro, Claudio; Gasperini, Claudio
- Abstract
Few long-term follow-up data are available on thyroid dysfunction (TD) in multiple sclerosis (MS) patients treated with glatiramer acetate (GA) or with interferon-beta (IFNb). In a cohort of 787 relapsing–remitting MS (RRMS) patients whom were followed up for 8 years, we observed an increased prevalence of TD and thyroid autoimmunity (TA) within the first year of IFNb treatment, regardless of the dose or frequency of administration, while no change was observed with GA treatment. The increased prevalence of TD and TA within the first year of IFNb treatment suggested the need for close monitoring of thyroid function and autoimmunity, though only during the first year of IFNb treatment.
- Subjects
MULTIPLE sclerosis treatment; AUTOIMMUNITY; INTERFERON beta-1a; GLATIRAMER acetate; THYROID gland function tests; DISEASE prevalence; DRUG dosage
- Publication
Multiple Sclerosis Journal, 2014, Vol 20, Issue 9, p1265
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/1352458514521311