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- Title
Treatment of Chronic Nonhealing Leg Ulceration with Gaseous Nitric Oxide: A Case Study.
- Authors
Miller, Chris C.; Miller, Minna K.; Abdi Ghaffari; Kunimoto, Brian K.
- Abstract
Background: Despite the best clinical practice, chronic nonhealing ulcers of the lower extremities present a significant challenge. Nitric oxide (NO) has been shown to play a significant role in biological functions including wound healing and as an antimicrobial agent in nonspecific immune response. Objective: Our goal was to study the effect of gaseous NO (gNO) administered directly to a two-year-old nonhealing chronic venous ulcer in a 55-year-old male presenting with a 30-year history of severe venous disease. Methods: gNO (200 ppm) was applied to the lower extremity using a delivery system connected to a ‘single patient use’ plastic boot, at 1.0 L/min. Results: The patient received an average of 8.1-h treatments for 14 consecutive nights. On day 0 the wound was malodorous and covered by bacterial biofilm with little healthy granulation tissue present. Following 3 days of gNO treatment, healthy granulation tissue was noted with absence of malodorous odor. At day 14, the ulcer was significantly reduced in size (p = 0.014) and almost completely reepithelialized. Day 10 post-treatment did not reveal an), deterioration in healing. Six weeks later, the wound was 90% healed. At 26 weeks post gNO discontinuation, the ulcer was completely healed. Conclusions: This single case study demonstrated that gNO as a topical agent was well tolerated by the patient without any report of discomfort or side effect. The result of wound healing was very promising and warrants future exploration.
- Subjects
NITRIC oxide; SKIN diseases; ANTI-infective agents; WOUND healing; DERMATOLOGIC agents; DERMATOLOGY; MEDICAL research
- Publication
Journal of Cutaneous Medicine & Surgery, 2004, Vol 8, Issue 4, p233
- ISSN
1203-4754
- Publication type
Article
- DOI
10.1007/s10227-004-0106-8