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- Title
Close linkage of the gene for Werner's syndrome to ANK1 and D8S87 on the short arm of chromosome 8.
- Authors
Nakura, J; Miki, T; Nagano, K; Kihara, K; Ye, L; Kamino, K; Fujiwara, Y; Yoshida, S; Murano, S; Fukuchi, K
- Abstract
Werner's syndrome (WRN) is a rare autosomal recessive disorder characterized by the appearance of features of premature aging in a young adult. Skin fibroblasts from WRN patient demonstrate slow growth, reduced life span in vitro and mutator phenotype. The genetic defect in WRN is unknown. We have studied 23 WRN patients mainly from first or second cousin marriage and have applied homozygosity mapping to search for the WRN locus. A peak lod score of 5.58 at a recombination fraction of 0.03 was obtained with D8S87. We confirmed that the WRN locus was located on the short arm of chromosome 8, 8p11.2-p12.
- Subjects
CHROMOSOMES; COMPARATIVE studies; CONSANGUINITY; DNA; GENE mapping; GENES; GENETICS; RESEARCH methodology; WERNER'S syndrome; GENETIC markers; EVALUATION research
- Publication
Gerontology, 1993, Vol 39, Issue 1, p11
- ISSN
0304-324X
- Publication type
journal article