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- Title
Genome-wideassociation study in Chineseidentifies novel loci for blood pressure and hypertension.
- Authors
Xiangfeng Lu; Laiyuan Wang; Xu Lin; Jianfeng Huang; Charles Gu, C.; Meian He; Hongbing Shen; Jiang He; Jingwen Zhu; Huaixing Li; James E. Hixson; Tangchun Wu; Juncheng Dai; Ling Lu; Chong Shen; Shufeng Chen; Lin He; Zengnan Mo; Yongchen Hao; Xingbo Mo
- Abstract
Hypertension is acommondisorder and the leading risk factor for cardiovascular disease and premature deaths worldwide. Genome-wide association studies (GWASs) in the European population have identified multiple chromosomal regions associated with blood pressure, and the identified loci altogether explain only a small fraction of the variance for bloodpressure.Thedifferences in environmental exposures andgenetic background between Chinese andEuropean populationsmight suggest potential different pathwaysof blood pressure regulation. To identify novel genetic variants affecting blood pressure variation, we conducted a meta-analysis of GWASs of blood pressure and hypertension in 11 816 subjects followed by replication studies including 69 146 additional individuals. We identified genome-wide significant (P < 5.0 x 10-8) associations with blood pressure, which included variants at three new loci (CACNA1D, CYP21A2, and MED13L) and a newly discovered variant near SLC4A7.We also replicated 14 previously reported loci, 8 (CASZ1,MOV10, FGF5, CYP17A1, SOX6, ATP2B1, ALDH2, and JAG1) at genome-wide significance, and 6 (FIGN, ULK4, GUCY1A3, HFE, TBX3-TBX5, and TBX3) at a suggestive level of P = 1.81 x 10-3 to 5.16 x 10-8. These findings provide new mechanistic insights into the regulation of blood pressure and potential targets for treatments.
- Publication
Human Molecular Genetics, 2015, Vol 24, Issue 3, p865
- ISSN
0964-6906
- Publication type
Article
- DOI
10.1093/hmg/ddu478