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Blockade of the pro‐fibrotic reaction mediated by the miR‐143/‐145 cluster enhances the responses to targeted therapy in melanoma.
Published in:
EMBO Molecular Medicine, 2022, v. 14, n. 3, p. 1, doi. 10.15252/emmm.202115295
By:
- Diazzi, Serena;
- Baeri, Alberto;
- Fassy, Julien;
- Lecacheur, Margaux;
- Marin‐Bejar, Oskar;
- Girard, Christophe A;
- Lefevre, Lauren;
- Lacoux, Caroline;
- Irondelle, Marie;
- Mounier, Carine;
- Truchi, Marin;
- Couralet, Marie;
- Ohanna, Mickael;
- Carminati, Alexandrine;
- Berestjuk, Ilona;
- Larbret, Frederic;
- Gilot, David;
- Vassaux, Georges;
- Marine, Jean‐Christophe;
- Deckert, Marcel
Publication type:
Article
CRISPR screens identify tumor‐promoting genes conferring melanoma cell plasticity and resistance.
Published in:
EMBO Molecular Medicine, 2021, v. 13, n. 5, p. 1, doi. 10.15252/emmm.202013466
By:
- Gautron, Arthur;
- Bachelot, Laura;
- Aubry, Marc;
- Leclerc, Delphine;
- Quéméner, Anaïs M;
- Corre, Sébastien;
- Rambow, Florian;
- Paris, Anaïs;
- Tardif, Nina;
- Leclair, Héloïse M;
- Marin‐Bejar, Oskar;
- Coulouarn, Cédric;
- Marine, Jean‐Christophe;
- Galibert, Marie‐Dominique;
- Gilot, David
Publication type:
Article
IGF2: The Achilles' heel of p53-deficiency?
Published in:
EMBO Molecular Medicine, 2012, v. 4, n. 8, p. 688, doi. 10.1002/emmm.201201509
By:
- Clermont, Frederic;
- Nittner, David;
- Marine, Jean-Christophe
Publication type:
Article
MDM4 is a rational target for treating breast cancers with mutant p53.
Published in:
Journal of Pathology, 2017, v. 241, n. 5, p. 661, doi. 10.1002/path.4877
By:
- Miranda, Panimaya Jeffreena;
- Buckley, Daniel;
- Raghu, Dinesh;
- Pang, Jia‐Min B;
- Takano, Elena A;
- Vijayakumaran, Reshma;
- Teunisse, Amina FAS;
- Posner, Atara;
- Procter, Tahlia;
- Herold, Marco J;
- Gamell, Cristina;
- Marine, Jean‐Christophe;
- Fox, Stephen B;
- Jochemsen, Aart;
- Haupt, Sue;
- Haupt, Ygal
Publication type:
Article
G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv.
Published in:
EMBO Journal, 2005, v. 24, n. 17, p. 3093, doi. 10.1038/sj.emboj.7600769
By:
- Doumont, Gilles;
- Martoriati, Alain;
- Beekman, Chantal;
- Bogaerts, Sven;
- Mee, Patrick J.;
- Bureau, Fabrice;
- Colombo, Emanuela;
- Alcalay, Myriam;
- Bellefroid, Eric;
- Marchesi, Francesco;
- Scanziani, Eugenio;
- Pelicci, Pier Giuseppe;
- Marine, Jean-Christophe
Publication type:
Article
A small amphipathic a-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5.
Published in:
EMBO Journal, 2000, v. 19, n. 3, p. 392, doi. 10.1093/emboj/19.3.392
By:
- Wang, Demin;
- Moriggl, Richard;
- Stravopodis, Dimitrios;
- Carpino, Nick;
- Marine, Jean-Christophe;
- Teglund, Stephan;
- Feng, Jian;
- Ihle, James N.
Publication type:
Article
Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice.
Published in:
2011
By:
- Migliorini, Domenico;
- Bogaerts, Sven;
- Defever, Dieter;
- Vyas, Rajesh;
- Geertrui Denecker;
- Radaelli, Enrico;
- Zwolinska, Aleksandra;
- Depaepe, Vanessa;
- Hochepied, Tino;
- Skarnes, William C.;
- Marine, Jean-Christophe;
- Denecker, Geertrui
Publication type:
journal article
Efficient mouse transgenesis using Gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells.
Published in:
Nucleic Acids Research, 2009, v. 37, n. 7, p. e55, doi. 10.1093/nar/gkp112
By:
- Nyabi, Omar;
- Naessens, Michael;
- Haigh, Katharina;
- Gembarska, Agnieszka;
- Goossens, Steven;
- Maetens, Marion;
- De Clercq, Sarah;
- Drogat, Benjamin;
- Haenebalcke, Lieven;
- Bartunkova, Sonia;
- De Vos, Ilse;
- De Craene, Bram;
- Karimi, Mansour;
- Berx, Geert;
- Nagy, Andras;
- Hilson, Pierre;
- Marine, Jean-Christophe;
- Haigh, Jody J.
Publication type:
Article
Reciprocal repression between P53 and TCTP.
Published in:
Nature Medicine, 2012, v. 18, n. 1, p. 91, doi. 10.1038/nm.2546
By:
- Amson, Robert;
- Pece, Salvatore;
- Lespagnol, Alexandra;
- Vyas, Rajesh;
- Mazzarol, Giovanni;
- Tosoni, Daniela;
- Colaluca, Ivan;
- Viale, Giuseppe;
- Rodrigues-Ferreira, Sylvie;
- Wynendaele, Jessika;
- Chaloin, Olivier;
- Hoebeke, Johan;
- Marine, Jean-Christophe;
- Di Fiore, Pier Paolo;
- Telerman, Adam
Publication type:
Article
Enhanced chromatin accessibility contributes to X chromosome dosage compensation in mammals.
Published in:
Genome Biology, 2021, v. 22, n. 1, p. 1, doi. 10.1186/s13059-021-02518-5
By:
- Talon, Irene;
- Janiszewski, Adrian;
- Theeuwes, Bart;
- Lefevre, Thomas;
- Song, Juan;
- Bervoets, Greet;
- Vanheer, Lotte;
- De Geest, Natalie;
- Poovathingal, Suresh;
- Allsop, Ryan;
- Marine, Jean-Christophe;
- Rambow, Florian;
- Voet, Thierry;
- Pasque, Vincent
Publication type:
Article
Spontaneous Post-Transplant Disorders in NOD.Cg- Prkdcscid Il2rgtm1Sug/JicTac (NOG) Mice Engrafted with Patient-Derived Metastatic Melanomas.
Published in:
PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0124974
By:
- Radaelli, Enrico;
- Hermans, Els;
- Omodho, Lorna;
- Francis, Annick;
- Vander Borght, Sara;
- Marine, Jean-Christophe;
- van den Oord, Joost;
- Amant, Frédéric
Publication type:
Article
Long non‐coding RNA TINCR suppresses metastatic melanoma dissemination by preventing ATF4 translation.
Published in:
EMBO Reports, 2021, v. 22, n. 3, p. 1, doi. 10.15252/embr.202050852
By:
- Melixetian, Marine;
- Bossi, Daniela;
- Mihailovich, Marija;
- Punzi, Simona;
- Barozzi, Iros;
- Marocchi, Federica;
- Cuomo, Alessandro;
- Bonaldi, Tiziana;
- Testa, Giuseppe;
- Marine, Jean‐Christophe;
- Leucci, Eleonora;
- Minucci, Saverio;
- Pelicci, Pier Giuseppe;
- Lanfrancone, Luisa
Publication type:
Article
dapk1, encoding an activator of a p19ARF-p53-mediated apoptotic checkpoint, is a transcription target of p53.
Published in:
Oncogene, 2005, v. 24, n. 8, p. 1461, doi. 10.1038/sj.onc.1208256
By:
- Martoriati, Alain;
- Doumont, Gilles;
- Alcalay, Myriam;
- Bellefroid, Eric;
- Pelicci, Pier Giuseppe;
- Marine, Jean-Christophe
Publication type:
Article
Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06951-2
By:
- Corre, Sébastien;
- Tardif, Nina;
- Mouchet, Nicolas;
- Leclair, Héloïse M.;
- Boussemart, Lise;
- Gautron, Arthur;
- Bachelot, Laura;
- Perrot, Anthony;
- Soshilov, Anatoly;
- Rogiers, Aljosja;
- Rambow, Florian;
- Dumontet, Erwan;
- Tarte, Karin;
- Bessede, Alban;
- Guillemin, Gilles J.;
- Marine, Jean-Christophe;
- Denison, Michael S.;
- Gilot, David;
- Galibert, Marie-Dominique
Publication type:
Article
Non-coding RNAs: the dark side of nuclear-mitochondrial communication.
Published in:
EMBO Journal, 2017, v. 36, n. 9, p. 1123, doi. 10.15252/embj.201695546
By:
- Vendramin, Roberto;
- Marine, Jean‐Christophe;
- Leucci, Eleonora
Publication type:
Article
MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output.
Published in:
EMBO Journal, 2010, v. 29, n. 15, p. 2538, doi. 10.1038/emboj.2010.140
By:
- Lihong Chen;
- Zhenyu Li;
- Zwolinska, Aleksandra K.;
- Smith, Matthew A.;
- Cross, Brittany;
- Koomen, John;
- Zhi-Min Yuan;
- Jenuwein, Thomas;
- Marine, Jean-Christophe;
- Wright, Kenneth L.;
- Jiandong Chen
Publication type:
Article
Epithelial‐to‐mesenchymal‐like transition events in melanoma.
Published in:
FEBS Journal, 2022, v. 289, n. 5, p. 1352, doi. 10.1111/febs.16021
By:
- Pedri, Dennis;
- Karras, Panagiotis;
- Landeloos, Ewout;
- Marine, Jean‐Christophe;
- Rambow, Florian
Publication type:
Article
Journal club.
Published in:
Nature, 2010, v. 464, n. 7293, p. 1249, doi. 10.1038/4641249e
By:
- Marine, Jean-Christophe
Publication type:
Article
Inactivation of the p53 pathway in retinoblastoma.
Published in:
Nature, 2006, v. 444, n. 7115, p. 61, doi. 10.1038/nature05194
By:
- Laurie, Nikia A.;
- Donovan, Stacy L.;
- Shih, Chie-Schin;
- Zhang, Jiakun;
- Mills, Nicholas;
- Fuller, Christine;
- Teunisse, Amina;
- Lam, Suzanne;
- Ramos, Yolande;
- Mohan, Adithi;
- Johnson, Dianna;
- Wilson, Matthew;
- Rodriguez-Galindo, Carlos;
- Quarto, Micaela;
- Francoz, Sarah;
- Mendrysa, Susan M.;
- Kiplin Guy, R.;
- Marine, Jean-Christophe;
- Jochemsen, Aart G.;
- Dyer, Michael A.
Publication type:
Article
Tyrosine-Dependent Phenotype Switching Occurs Early in Many Primary Melanoma Cultures Limiting Their Translational Value.
Published in:
Frontiers in Oncology, 2021, v. 11, p. 1, doi. 10.3389/fonc.2021.780654
By:
- Najem, Ahmad;
- Wouters, Jasper;
- Krayem, Mohammad;
- Rambow, Florian;
- Sabbah, Malak;
- Sales, François;
- Awada, Ahmad;
- Aerts, Stein;
- Journe, Fabrice;
- Marine, Jean-Christophe;
- Ghanem, Ghanem E.
Publication type:
Article
Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation.
Published in:
Nature Cell Biology, 2012, v. 14, n. 9, p. 958, doi. 10.1038/ncb2556
By:
- Nittner, David;
- Lambertz, Irina;
- Clermont, Frederic;
- Mestdagh, Pieter;
- Köhler, Corinna;
- Nielsen, Søren Jensby;
- Jochemsen, Aart;
- Speleman, Frank;
- Vandesompele, Jo;
- Dyer, Michael A.;
- Schramm, Alexander;
- Schulte, Johannes H.;
- Marine, Jean-Christophe
Publication type:
Article
Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death.
Published in:
Nature Cell Biology, 2010, v. 12, n. 6, p. 572, doi. 10.1038/ncb2059
By:
- Sotiropoulou, Panagiota A.;
- Candi, Aurélie;
- Mascré, Guilhem;
- De Clercq, Sarah;
- Youssef, Khalil Kass;
- Lapouge, Gaelle;
- Dahl, Ellen;
- Semeraro, Claudio;
- Denecker, Geertrui;
- Marine, Jean-Christophe;
- Blanpain, Cédric
Publication type:
Article
Nucleophosmin regulates the stability and transcriptional activity of p53.
Published in:
Nature Cell Biology, 2002, v. 4, n. 7, p. 529, doi. 10.1038/ncb814
By:
- Colombo, Emanuela;
- Marine, Jean-Christophe;
- Danovi, Davide;
- Falini, Brunangelo;
- Pelicci, Pier Giuseppe
Publication type:
Article
iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track Collections.
Published in:
PLoS Computational Biology, 2014, v. 10, n. 7, p. 1, doi. 10.1371/journal.pcbi.1003731
By:
- Janky, Rekin's;
- Verfaillie, Annelien;
- Imrichová, Hana;
- Van de Sande, Bram;
- Standaert, Laura;
- Christiaens, Valerie;
- Hulselmans, Gert;
- Herten, Koen;
- Naval Sanchez, Marina;
- Potier, Delphine;
- Svetlichnyy, Dmitry;
- Kalender Atak, Zeynep;
- Fiers, Mark;
- Marine, Jean-Christophe;
- Aerts, Stein
Publication type:
Article
Comparative oncogenomics identifies tyrosine kinase FES as a tumor suppressor in melanoma.
Published in:
2017
By:
- Olvedy, Michael;
- Tisserand, Julie C.;
- Luciani, Flavie;
- Boeckx, Bram;
- Wouters, Jasper;
- Lopez, Sophie;
- Rambow, Florian;
- Aibar, Sara;
- Thienpont, Bernard;
- Barra, Jasmine;
- Köhler, Corinna;
- Radaelli, Enrico;
- Tartare-Deckert, Sophie;
- Aerts, Stein;
- Dubreuil, Patrice;
- van den Oord, Joost J.;
- Lambrechts, Diether;
- De Sepulveda, Paulo;
- Marine, Jean-Christophe
Publication type:
journal article
Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state.
Published in:
Nature Communications, 2015, v. 6, n. 4, p. 6683, doi. 10.1038/ncomms7683
By:
- Verfaillie, Annelien;
- Imrichova, Hana;
- Atak, Zeynep Kalender;
- Dewaele, Michael;
- Rambow, Florian;
- Hulselmans, Gert;
- Christiaens, Valerie;
- Svetlichnyy, Dmitry;
- Luciani, Flavie;
- Van den Mooter, Laura;
- Claerhout, Sofie;
- Fiers, Mark;
- Journe, Fabrice;
- Ghanem, Ghanem-Elias;
- Herrmann, Carl;
- Halder, Georg;
- Marine, Jean-Christophe;
- Aerts, Stein
Publication type:
Article
The Doublesex Homolog Dmrt5 is Required for the Development of the Caudomedial Cerebral Cortex in Mammals.
Published in:
Cerebral Cortex, 2013, v. 23, n. 11, p. 2552, doi. 10.1093/cercor/bhs234
By:
- Saulnier, Amandine;
- Keruzore, Marc;
- De Clercq, Sarah;
- Bar, Isabelle;
- Moers, Virginie;
- Magnani, Dario;
- Walcher, Tessa;
- Filippis, Carol;
- Kricha, Sadia;
- Parlier, Damien;
- Viviani, Laurène;
- Matson, Clinton K.;
- Nakagawa, Yasushi;
- Theil, Thomas;
- Götz, Magdalena;
- Mallamaci, Antonello;
- Marine, Jean-Christophe;
- Zarkower, David;
- Bellefroid, Eric J.
Publication type:
Article
Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04664-0
By:
- Talebi, Ali;
- Dehairs, Jonas;
- Rambow, Florian;
- Rogiers, Aljosja;
- Nittner, David;
- Derua, Rita;
- Vanderhoydonc, Frank;
- Duarte, Joao A. G.;
- Bosisio, Francesca;
- Van den Eynde, Kathleen;
- Nys, Kris;
- Pérez, Mónica Vara;
- Agostinis, Patrizia;
- Waelkens, Etienne;
- Van den Oord, Joost;
- Fendt, Sarah-Maria;
- Marine, Jean-Christophe;
- Swinnen, Johannes V.
Publication type:
Article
Exploring the role of Fragile X Mental Retardation Protein in melanoma progression and invasiveness-related pathways in melanoma cells.
Published in:
2018
By:
- Carotti, Simone;
- Zalfa, Francesca;
- Panasiti, Vincenzo;
- Zingariello, Maria;
- Roberti, Vincenzo;
- Sancillo, Laura;
- Perrone, Giuseppe;
- Rana, Rosa Alba;
- Marine, Jean-Christophe;
- Bagni, Claudia;
- Morini, Sergio
Publication type:
Abstract
Loss of oocytes due to conditional ablation of Murine double minute 2 ( Mdm2) gene is p53-dependent and results in female sterility.
Published in:
FEBS Letters, 2016, v. 590, n. 16, p. 2566, doi. 10.1002/1873-3468.12275
By:
- Livera, Gabriel;
- Uzbekov, Rustem;
- Jarrier, Peggy;
- Fouchécourt, Sophie;
- Duquenne, Clotilde;
- Parent, Anne-Simone;
- Marine, Jean-Christophe;
- Monget, Philippe
Publication type:
Article
Comparative single-cell RNA-sequencing profiling of BMP4-treated primary glioma cultures reveals therapeutic markers.
Published in:
Neuro-Oncology, 2022, v. 24, n. 12, p. 2133, doi. 10.1093/neuonc/noac143
By:
- Verploegh, Iris S C;
- Conidi, Andrea;
- Brouwer, Rutger W W;
- Balcioglu, Hayri E;
- Karras, Panagiotis;
- Makhzami, Samira;
- Korporaal, Anne;
- Marine, Jean-Christophe;
- Lamfers, Martine;
- IJcken, Wilfred F J Van;
- Leenstra, Sieger;
- Huylebroeck, Danny
Publication type:
Article
Novel Therapies for Metastatic Melanoma: An Update on Their Use in Older Patients.
Published in:
Drugs & Aging, 2015, v. 32, n. 10, p. 821, doi. 10.1007/s40266-015-0304-7
By:
- Rogiers, Aljosja;
- Oord, Joost;
- Garmyn, Marjan;
- Stas, Marguerite;
- Kenis, Cindy;
- Wildiers, Hans;
- Marine, Jean-Christophe;
- Wolter, Pascal
Publication type:
Article
Translation rewiring at the heart of phenotype switching in melanoma.
Published in:
Pigment Cell & Melanoma Research, 2017, v. 30, n. 3, p. 282, doi. 10.1111/pcmr.12583
By:
- Leucci, Eleonora;
- Close, Pierre;
- Marine, Jean ‐ Christophe
Publication type:
Article
The emerging role of long non-coding RNAs in cutaneous melanoma.
Published in:
Pigment Cell & Melanoma Research, 2016, v. 29, n. 6, p. 619, doi. 10.1111/pcmr.12537
By:
- Leucci, Eleonora;
- Coe, Elizabeth A.;
- Marine, Jean‐Christophe;
- Vance, Keith W.
Publication type:
Article
Regulation of SIRT6 protein levels by nutrient availability
Published in:
FEBS Letters, 2008, v. 582, n. 5, p. 543, doi. 10.1016/j.febslet.2008.01.019
By:
- Kanfi, Yariv;
- Shalman, Ronnie;
- Peshti, Victoria;
- Pilosof, Shmuel N.;
- Gozlan, Yosi M.;
- Pearson, Kevin J.;
- Lerrer, Batya;
- Moazed, Danesh;
- Marine, Jean-Christophe;
- de Cabo, Rafael;
- Cohen, Haim Y.
Publication type:
Article
Gain of function of mutant p53 by coaggregation with multiple tumor suppressors.
Published in:
Nature Chemical Biology, 2011, v. 7, n. 5, p. 285, doi. 10.1038/nchembio.546
By:
- Xu, Jie;
- Reumers, Joke;
- Couceiro, José R;
- De Smet, Frederik;
- Gallardo, Rodrigo;
- Rudyak, Stanislav;
- Cornelis, Ann;
- Rozenski, Jef;
- Zwolinska, Aleksandra;
- Marine, Jean-Christophe;
- Lambrechts, Diether;
- Young-Ah Suh;
- Rousseau, Frederic;
- Schymkowitz, Joost
Publication type:
Article
Spotlight on the role of COP1 in tumorigenesis.
Published in:
Nature Reviews Cancer, 2012, v. 12, n. 7, p. 455, doi. 10.1038/nrc3271
By:
- Marine, Jean-Christophe
Publication type:
Article
Antitumor Activity of the Selective MDM2 Antagonist Nutlin-3 Against Chemoresistant Neuroblastoma With Wild-Type p53.
Published in:
JNCI: Journal of the National Cancer Institute, 2009, v. 101, n. 22, p. 1562, doi. 10.1093/jnci/djp355
By:
- Van Maerken, Tom;
- Ferdinande, Liesbeth;
- Taildeman, Jasmien;
- Lambertz, Irina;
- Yigit, Nurten;
- Vercruysse, Liesbeth;
- Rihani, Ali;
- Michaelis, Martin;
- Cinatl Jr., Jindrich;
- Cuvelier, Claude A.;
- Marine, Jean-Christophe;
- De Paepe, Anne;
- Bracke, Marc;
- Speleman, Frank;
- Vandesompele, Jo
Publication type:
Article
Classification and Grading of Melanocytic Lesions in a Mouse Model of NRAS -driven Melanomagenesis.
Published in:
Journal of Histochemistry & Cytochemistry, 2021, v. 69, n. 3, p. 203, doi. 10.1369/0022155420977970
By:
- Assenmacher, Charles-Antoine;
- Santagostino, Sara F.;
- Oyama, Mark A.;
- Marine, Jean-Christophe;
- Bonvin, Elise;
- Radaelli, Enrico
Publication type:
Article
The X-linked trichothiodystrophy-causing gene RNF113A links the spliceosome to cell survival upon DNA damage.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-15003-7
By:
- Shostak, Kateryna;
- Jiang, Zheshen;
- Charloteaux, Benoit;
- Mayer, Alice;
- Habraken, Yvette;
- Tharun, Lars;
- Klein, Sebastian;
- Xu, Xinyi;
- Duong, Hong Quan;
- Vislovukh, Andrii;
- Close, Pierre;
- Florin, Alexandra;
- Rambow, Florian;
- Marine, Jean-Christophe;
- Büttner, Reinhard;
- Chariot, Alain
Publication type:
Article
Siah2 control of T-regulatory cells limits anti-tumor immunity.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-019-13826-7
By:
- Scortegagna, Marzia;
- Hockemeyer, Kathryn;
- Dolgalev, Igor;
- Poźniak, Joanna;
- Rambow, Florian;
- Li, Yan;
- Feng, Yongmei;
- Tinoco, Roberto;
- Otero, Dennis C.;
- Zhang, Tongwu;
- Brown, Kevin;
- Bosenberg, Marcus;
- Bradley, Linda M.;
- Marine, Jean-Christophe;
- Aifantis, Ioannis;
- Ronai, Ze'ev A.
Publication type:
Article

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