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- Title
Expedient Construction of the [5-6-7] Tricyclic Core of Calyciphylline A-Type Alkaloids.
- Authors
Guo, Jing ‐ Jing; Li, Yun; Cheng, Bin; Xu, Tingting; Tao, Cheng; Yang, Xinkan; Zhang, Denghong; Yan, Guangqi; Zhai, Hongbin
- Abstract
An efficient synthetic route toward the highly congested [5-6-7] tricyclic core of calyciphylline A-type alkaloids has been developed. This approach features a highly efficient intramolecular Diels-Alder cycloaddition to establish the aza-five-membered C ring as well as the C1 all-carbon quaternary center, and a subsequent cyclopropanation together with a ring-expansion reaction of the resulted adduct to construct the seven-membered D ring.
- Subjects
MOLECULAR structure of alkaloids; ALKALOID synthesis; DIELS-Alder reaction; NERVE growth factor; RING formation (Chemistry)
- Publication
Chemistry - An Asian Journal, 2015, Vol 10, Issue 4, p865
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.201403061