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- Title
Readily Available Immobilized Pd Catalysts for Suzuki‐Miyaura Coupling under Continuous‐flow Conditions.
- Authors
Ichitsuka, Tomohiro; Suzuki, Naoto; Sairenji, Masaki; Koumura, Nagatoshi; Onozawa, Shun‐ya; Sato, Kazuhiko; Kobayashi, Shū
- Abstract
Highly efficient immobilized catalysts for continuous‐flow cross‐coupling reactions that show better productivity than those for the corresponding batch reactions are increasingly in demand. For practical use, such catalysts should have highly catalytic activity and high leaching resistance. To find catalysts suitable for continuous‐flow conditions, we have developed a consistent method for evaluating the catalytic performance of commercially available immobilized Pd catalysts. Monitoring of the change in turnover frequency over time under excess substrate loading conditions revealed the limitation of these catalysts. On the basis of the evaluation results, we have successfully developed a new immobilized Pd catalyst that exhibited highly efficient and robust catalytic performance.
- Subjects
PALLADIUM catalysts; SUZUKI reaction; FLOW chemistry; COUPLING reactions (Chemistry); CATALYTIC activity
- Publication
ChemCatChem, 2019, Vol 11, Issue 10, p2427
- ISSN
1867-3880
- Publication type
Article
- DOI
10.1002/cctc.201900085