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- Title
Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice.
- Authors
De Palma, Giada; Lynch, Michael D. J.; Jun Lu; Dang, Vi T.; Yikang Deng; Jury, Jennifer; Umeh, Genevieve; Miranda, Pedro M.; Pastor, Marc Pigrau; Sidani, Sacha; Pinto-Sanchez, Maria Ines; Philip, Vivek; McLean, Peter G.; Hagelsieb, Moreno-Gabriel; Surette, Michael G.; Bergonzelli, Gabriela E.; Verdu, Elena F.; Britz-McKibbin, Philip; Neufeld, Josh D.; Collins, Stephen M.
- Abstract
The article discusses the transplantation of gut microbiota from patients with irritable bowel syndrome (IBS). It examines the functional role of gut bacteria by colonizing a germ-free mice with a fecal microbiota from healthy control individuals and IBS patients with diarrhea (IBS-D). It notes that the mice receiving the IBS-D fecal microbiota showed a similar microbial composition to that of mice receiving the healthy control fecal microbiota.
- Subjects
GUT microbiome; IRRITABLE colon; LABORATORY mice; DIARRHEA; INTESTINAL diseases; PATIENTS
- Publication
Science Translational Medicine, 2017, Vol 9, Issue 379, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aaf6397