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- Title
Peri-Articular Injection of Tranexamic Acid Reduce Blood Loss and Transfusion Requirement During Total Knee Arthroplasty: A Meta-analysis.
- Authors
Liu, Yue; Shan, Duo; Tian, Peng; Li, Zhi-jun; Xu, Gui-jun; Fu, Xin
- Abstract
Background: The aim of this meta-analysis was to evaluate the efficacy and safety of peri-articular injection of tranexamic acid (TXA) during total knee arthroplasty (TKA) from clinical controlled trials. Method: Eligible scientific articles published prior to October 2021 were retrieved from the PubMed, Springer, ScienceDirect and Cochrane Library databases. The statistical analysis was performed with RevMan 5.1. Result: 2 RCTs and 3 non-RCTs met the inclusion criteria. Meta-analysis showed significant differences in terms of hemoglobin reduction (MD = −1.04, 95% CI: −1.33 to −.76, P <.00001), total blood loss (MD = −342.80.70, 95% CI: −437.52 to −248.08, P <.00001), drainage volume (MD = −297.24, 95% CI: −497.26 to −97.23, P =.004) and blood transfusion rate (OR =.30, 95% CI:.14 to.62, P =.001) were found in the control group. No postoperative infection and deep venous thrombosis were found between 2 groups. Conclusion: Peri-articular injection of TXA can effectively decrease perioperative blood loss and blood transfusion rate without increasing the incidence of postoperative complications during TKA.
- Subjects
SURGICAL blood loss; DRUG efficacy; ONLINE information services; MEDICAL databases; TOTAL knee replacement; META-analysis; INJECTIONS; CONFIDENCE intervals; HEMOGLOBINS; BLOOD transfusion; SYSTEMATIC reviews; TRANEXAMIC acid; DESCRIPTIVE statistics; MEDLINE; DATA analysis software; ODDS ratio
- Publication
Geriatric Orthopaedic Surgery & Rehabilitation, 2022, Vol 13, p1
- ISSN
2151-4585
- Publication type
Article
- DOI
10.1177/21514593221101264