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- Title
GLC-MS profiling of non-polar extracts from Phlomis bucharica and P. salicifolia and their cytotoxicity.
- Authors
MAMADALIEVA, Nilufar Z.; VINCIGUERRA, Vittorio; SOBEH, Mansour; OVIDI, Elisa; ASHOUR, Mohamed L.; WINK, Michael; TIEZZI, Antonio
- Abstract
Phlomis species (Phlomis bucharica Regel and P. salicifolia Regel) have been traditionally used by Uzbek people as stimulant, tonic, diuretic, and in the treatment of ulcers, hemorrhoids, wounds and gynecological problems. In the present study, we characterized the chemical composition of non-polar extracts from P. bucharica and P. salicifolia by high resolution GLC-MS and evaluated their cytotoxicity. Concentrations of hexadecanoic acid in hexane and chloroform extracts were higher in P. bucharica than in P. salicifolia. 1,8-Cineol, camphor, borneol, α-terpinol, thymol, and isobornyl acetate were detected in P. bucharica but not in P. salicifolia. About 45 components were identified in P. bucharica and 40 in P. salicifolia. The chloroform extract from P. bucharica showed cytotoxicity in HeLa and HL-60 cells, with IC50 values of 26.07 and 29.42 μ/ml, respectively.
- Subjects
PHLOMIS; PHYTOTHERAPY; THERAPEUTIC use of plant extracts; THERAPEUTICS
- Publication
Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 2015, Vol 14, Issue 6, p442
- ISSN
0717-7917
- Publication type
Article